8-bromocinnoline

Base Information

• Chemical Name: 8-bromocinnoline
• CAS No.: 67888-34-0
• Molecular Formula: C₈H₅BrN₂
• Molecular Weight: 209.045
• Mol file: 67888-34-0.mol

Synonyms:8-Bromocinnoline;

Chemical Property of 8-bromocinnoline

Chemical Property:

• Refractive Index: 1.685
• Boiling Point: 325 °C at 760 mmHg
• Flash Point: 150.3 °C
• Density: 1.656 g/cm³
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98%min ^*data from raw suppliers

8-Bromocinnoline 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 8-bromocinnoline

There total 2 articles about 8-bromocinnoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

Cinnoline (253-66-7) → 8-bromocinnoline (67888-34-0)

Guidance literature:

Cinnoline; With 2,2,6,6-tetramethylpiperidinylmagnesium chloride lithium chloride complex; zinc(II) chloride; In tetrahydrofuran; at 50 ℃; for 3h; Inert atmosphere;

With bromine; In tetrahydrofuran; 1,4-dioxane; at -78 - 25 ℃; regioselective reaction; Further stages; Inert atmosphere;

DOI:10.1021/ol5001999

Reference yield:

→ 8-bromocinnoline (67888-34-0)

Guidance literature:

entspr. 8-Aminoverb. via Diazoniumsalz mit CuBr/Cu;

DOI:10.1016/0040-4020(78)88143-5

upstream raw materials:

Cinnoline

Refernces

• 1、 Klatt, Thomas,Roman, Daniela Sustac,Leon, Thierry,Knochel, Paul. "TMP-magnesium and TMP-Zinc bases for the regioselective metalation of the cinnoline scaffold". supporting information. p. 1232 - 1235. Retrieved 2014/03/21.