2-Bromo-5-chloronicotinic acid

Base Information

• Chemical Name: 2-Bromo-5-chloronicotinic acid
• CAS No.: 65550-79-0
• Molecular Formula: C6H3 Br Cl N O2
• Molecular Weight: 236.45
• Hs Code.: 2933399090
• Mol file: 65550-79-0.mol

Synonyms:2-Bromo-5-chloronicotinicacid

Chemical Property of 2-Bromo-5-chloronicotinic acid

Chemical Property:

• Boiling Point: 343.1±42.0 °C(Predicted)
• PKA: 1.75±0.10(Predicted)
• PSA: 50.19000
• Density: 1.917±0.06 g/cm3(Predicted)
• LogP: 2.19570

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-Bromo-5-chloronicotinicacid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Bromo-5-chloronicotinic acid

There total 1 articles about 2-Bromo-5-chloronicotinic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ 2-bromo-5-chloronicotinic acid (65550-79-0)

Guidance literature:

3-Picolinderivat II; Oxidation;

DOI:10.1016/S1352-2310(00)00235-1

Reference yield: 70.0%

Cyclohexyl isocyanide (931-53-3) + 2-bromo-5-chloronicotinic acid (65550-79-0) + 3,4,5-trimethoxy-benzaldehyde (86-81-7) + Propargylamine (2450-71-7) → 2-bromo-5-chloro-N-(2-(cyclohexylamino)-2-oxo-1-(3,4,5-trimethoxyphenyl)ethyl)-N-(prop-2-yn-1-yl)nicotinamide

Guidance literature:

3,4,5-trimethoxy-benzaldehyde; Propargylamine; In methanol; at 20 ℃; for 0.5h; Inert atmosphere;

2-bromo-5-chloronicotinic acid; In methanol; at 20 ℃; for 0.25h; Inert atmosphere;

Cyclohexyl isocyanide; In methanol; at 20 ℃; for 48h; Temperature; Inert atmosphere;

DOI:10.1021/acs.joc.9b02712

Reference yield: 48.0%

benzyl bromide (100-39-0) + 2-bromo-5-chloronicotinic acid (65550-79-0) → benzyl 2-bromo-5-chloronicotinate

Guidance literature:

With potassium carbonate; In acetonitrile; at 18 - 25 ℃; for 24h;