methyl 4-(tert-butoxycarbonylamino)-5-(2-iodophenylamino)-5-oxopentanoate

Base Information

• Chemical Name: methyl 4-(tert-butoxycarbonylamino)-5-(2-iodophenylamino)-5-oxopentanoate
• CAS No.: 1298035-68-3
• Molecular Formula: C₁₇H₂₃IN₂O₅
• Molecular Weight: 462.285
• Mol file: 1298035-68-3.mol

Synonyms:methyl 4-(tert-butoxycarbonylamino)-5-(2-iodophenylamino)-5-oxopentanoate

Chemical Property of methyl 4-(tert-butoxycarbonylamino)-5-(2-iodophenylamino)-5-oxopentanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 4-(tert-butoxycarbonylamino)-5-(2-iodophenylamino)-5-oxopentanoate

There total 1 articles about methyl 4-(tert-butoxycarbonylamino)-5-(2-iodophenylamino)-5-oxopentanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

2-iodophenylamine (615-43-0) + (2S)-2-[(tert-butoxy)carbonylamino]-4-(methoxycarbonyl)butanoic acid (45214-91-3) → methyl 4-(tert-butoxycarbonylamino)-5-(2-iodophenylamino)-5-oxopentanoate (1298035-68-3)

Guidance literature:

(2S)-2-[(tert-butoxy)carbonylamino]-4-(methoxycarbonyl)butanoic acid; With dmap; dicyclohexyl-carbodiimide; In dichloromethane; at 20 ℃; for 0.166667h; Inert atmosphere;

2-iodophenylamine; In dichloromethane; at 20 ℃; Inert atmosphere;

DOI:10.1055/s-0030-1259302

Reference yield:

methyl 4-(tert-butoxycarbonylamino)-5-(2-iodophenylamino)-5-oxopentanoate (1298035-68-3) → C12H15IN2O3

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 2h; Inert atmosphere;

DOI:10.1055/s-0030-1259302

Reference yield:

methyl 4-(tert-butoxycarbonylamino)-5-(2-iodophenylamino)-5-oxopentanoate (1298035-68-3) → methyl 3-(5-(2-iodophenylamino)-2-methyloxazol-4-yl)propanoate (1298035-50-3)

Guidance literature:

Multi-step reaction with 3 steps

1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C / Inert atmosphere

2: pyridine / tetrahydrofuran / 4 h / 20 °C / Inert atmosphere

3: trifluoroacetic acid; trifluoroacetic anhydride / dichloromethane / 36 h / 20 °C / Inert atmosphere

With pyridine; trifluoroacetic acid; trifluoroacetic anhydride; In tetrahydrofuran; dichloromethane;

DOI:10.1055/s-0030-1259302

upstream raw materials:

2-iodophenylamine

(2S)-2-[(tert-butoxy)carbonylamino]-4-(methoxycarbonyl)butanoic acid

Downstream raw materials:

methyl 3-(5-(2-iodophenylamino)-2-methyloxazol-4-yl)propanoate

methyl 3-(5-((2-iodophenyl)(methyl)amino)-2-methyloxazol-4-yl)propanoate

methyl 3-(5-((benzyl)-(2-iodophenyl)amino)-2-methyloxazol-4-yl)propanoate

methyl 3-(9-benzyl-3-methyl-9H-pyrido[3,4-b]indol-1-yl)propanoate

Refernces