3-[2-(3-Chlorophenyl)ethyl]-2-pyridyl 1-methyl-4-piperidyl ketone hydrochloride

Base Information

• Chemical Name: 3-[2-(3-Chlorophenyl)ethyl]-2-pyridyl 1-methyl-4-piperidyl ketone hydrochloride
• CAS No.: 107256-31-5
• Molecular Formula: C₂₀H₂₃ClN₂O*ClH
• Molecular Weight: 379.329
• Mol file: 107256-31-5.mol

Synonyms:Methanone,[3-[2-(3-chlorophenyl)ethyl]-2-pyridinyl](1-methyl-4-piperidinyl)-,hydrochloride (9CI)

Chemical Property of 3-[2-(3-Chlorophenyl)ethyl]-2-pyridyl 1-methyl-4-piperidyl ketone hydrochloride

Chemical Property:

• Vapor Pressure: 6.6E-10mmHg at 25°C
• Boiling Point: 487.9oC at 760 mmHg
• Flash Point: 248.9oC
• PSA: 33.20000
• LogP: 4.78460

Purity/Quality:

98%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-[2-(3-Chlorophenyl)ethyl]-2-pyridyl 1-methyl-4-piperidyl ketone hydrochloride

There total 10 articles about 3-[2-(3-Chlorophenyl)ethyl]-2-pyridyl 1-methyl-4-piperidyl ketone hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.3%

4-chloro-1-methylpiperidine (5570-77-4) + 3-[2-(3-chlorophenyl)ethyl]-2-pyridine-carbonitrile (31255-57-9) → 1-(METHYL-4-PIPERIDINYL)[3-(2-(3-CHLORO-PHENYL)ETHYL)-2-PYRIDINYL]METHANONE HYDROCHLORIDE (119770-60-4,107256-31-5)

Guidance literature:

4-chloro-1-methylpiperidine; With iodine; magnesium; In tetrahydrofuran; ethylene dibromide; at 75 ℃; for 1h; Inert atmosphere;

3-[2-(3-chlorophenyl)ethyl]-2-pyridine-carbonitrile; In tetrahydrofuran; ethylene dibromide; at 40 - 50 ℃; for 1h; Inert atmosphere;

With hydrogenchloride; water; In tetrahydrofuran; ethylene dibromide; at 20 ℃; for 1h; pH=< 2; Inert atmosphere;

Reference yield: 48.6%

3-[2-(3-chlorophenyl)ethyl]-2-pyridine-carbonitrile (31255-57-9) + (1-methyl-4-piperidyl)magnesium chloride (63463-36-5) → 1-(METHYL-4-PIPERIDINYL)[3-(2-(3-CHLORO-PHENYL)ETHYL)-2-PYRIDINYL]METHANONE HYDROCHLORIDE (119770-60-4,107256-31-5)

Guidance literature:

In tetrahydrofuran; at 30 - 60 ℃; for 1.5h;

Reference yield:

N-methyl-piperidyl magnesium chloride + 3-[2-(3-chlorophenyl)ethyl]-2-pyridine-carbonitrile (31255-57-9) → 1-(METHYL-4-PIPERIDINYL)[3-(2-(3-CHLORO-PHENYL)ETHYL)-2-PYRIDINYL]METHANONE HYDROCHLORIDE (119770-60-4,107256-31-5)

Guidance literature:

With hydrogenchloride; sodium hydroxide; In tetrahydrofuran;

upstream raw materials:

2-cyano-3-methylpyridine

N-tert-butyl-3-methylpyridine-2-carboxamide

3-[2-(3-chlorophenyl)ethyl]-2-pyridine-carbonitrile

3-<2-(3-chlorophenyl)ethyl>-N-(1,1-dimethylethyl)-2-pyridinecarboxamide

Downstream raw materials:

loratadine

Refernces

• 1、 -. "Preparation method of loratadine intermediate". . . Retrieved 2021/04/29.
• 2、 -. "Tricyclic carbamate compounds useful for inhibition of G-protein function and for treatment of proliferative diseases". . . Retrieved 2008/06/13.