4-CHLORO-6-METHYLTHIOPYRIMIDINE

Base Information

• Chemical Name: 4-CHLORO-6-METHYLTHIOPYRIMIDINE
• CAS No.: 89283-48-7
• Molecular Formula: C5H5ClN2S
• Molecular Weight: 160.627
• Hs Code.: 2933599090
• Mol file: 89283-48-7.mol

Synonyms:4-Chloro-6-methylsulfanylpyrimidine;4-Chloro-6-methylthiopyrimidine;Pyrimidine, 4-chloro-6-(methylthio)-;

Chemical Property of 4-CHLORO-6-METHYLTHIOPYRIMIDINE

Chemical Property:

• Vapor Pressure: 0.02mmHg at 25°C
• Melting Point: 50-51 °C
• Refractive Index: 1.595
• Boiling Point: 260.229 °C at 760 mmHg
• PKA: -1.50±0.17(Predicted)
• Flash Point: 111.183 °C
• PSA: 51.08000
• Density: 1.37 g/cm³
• LogP: 1.85190
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature

Purity/Quality:

98%,99%, ^*data from raw suppliers

4-Chloro-6-methylthiopyrimidine ^*data from reagent suppliers

Safty Information:

• Statements: 43
• Safety Statements: 36/37

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-CHLORO-6-METHYLTHIOPYRIMIDINE

There total 4 articles about 4-CHLORO-6-METHYLTHIOPYRIMIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

4,6-dichloropyrimidine (1193-21-1) + sodium thiomethoxide (5188-07-8) → 4-chloro-6-methylsulfanylpyrimidine (89283-48-7)

Guidance literature:

In tetrahydrofuran; at 20 - 60 ℃; for 16h;

Reference yield: 31.0%

4,6-dichloropyrimidine (1193-21-1) + boron dimethyl-trifluoro sulphide (353-43-5) → 4-chloro-6-methylsulfanylpyrimidine (89283-48-7) + 4,6-bis(methylthio)pyrimidine (1450-90-4)

Guidance literature:

In neat (no solvent); at 60 ℃; for 16h; Sealed tube;

DOI:10.1002/ejoc.201900503

Reference yield:

4,6-dichloropyrimidine (1193-21-1) + sodium thiomethoxide (5188-07-8) → 4-chloro-6-methylsulfanylpyrimidine (89283-48-7) + 4,6-bis(methylthio)pyrimidine (1450-90-4)

Guidance literature:

In tetrahydrofuran; at 20 ℃;

upstream raw materials:

4,6-dichloropyrimidine

sodium thiomethoxide

boron dimethyl-trifluoro sulphide

Downstream raw materials:

N-(3-(2-(6-methanesulfinylpyrimidin-4-yl)-5-methyl-2H-pyrazol-3-ylamino)-4-methylphenyl)-3-trifluoromethylbenzamide

N-(4-methyl-3-(5-methyl-2-(6-methylsulfanylpyrimidin-4-yl)-2H-pyrazol-3-ylamino)-phenyl)-3-trifluoromethylbenzamide

4-chloro-6-(methylsulfonyl)pyrimidine

(6-methylsulfanylpyrimidin-4-yl)hydrazine

Refernces

• 1、 Kamijo, Shin,Kamijo, Kaori,Murafuji, Toshihiro. "Synthesis of Alkylated Pyrimidines via Photoinduced Coupling Using Benzophenone as a Mediator". . p. 2664 - 2671. Retrieved 2017/03/14.
• 2、 -. "COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS". Page/Page column 26-27. . Retrieved 2011/09/14.