5-Chloro-3-methylpyrazole

Base Information

• Chemical Name: 5-Chloro-3-methylpyrazole
• CAS No.: 15953-45-4
• Molecular Formula: C4H5ClN2
• Molecular Weight: 116.55
• Hs Code.: 2933199090
• Mol file: 15953-45-4.mol

Synonyms:Pyrazole,3(or 5)-chloro-5(or 3)-methyl- (7CI);Pyrazole, 3-chloro-5-methyl- (8CI);3-Methyl-5-chloropyrazole;5-Chloro-3-methylpyrazole;NSC 243512;

Chemical Property of 5-Chloro-3-methylpyrazole

Chemical Property:

• Vapor Pressure: 0.0213mmHg at 25°C
• Melting Point: 118.5°C
• Refractive Index: 1.551
• Boiling Point: 259.1 °C at 760 mmHg
• Flash Point: 135.6 °C
• PSA: 28.68000
• Density: 1.306 g/cm³
• LogP: 1.37150
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

5-chloro-3-methyl-1H-pyrazole ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-Chloro-3-methylpyrazole

There total 6 articles about 5-Chloro-3-methylpyrazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

5-chloro-1,3-dimethyl-pyrazole (54454-10-3) → 5-chloro-3-methyl-1H-pyrazole (15953-45-4)

Guidance literature:

With pyridine hydrochloride; at 200 ℃; for 2h; Product distribution / selectivity; Irradiation;

Reference yield: 33.0%

5-chloro-1-(2-chlorobenzenesulfonyl)-3-methylpyrazole (881668-68-4) → 5-chloro-3-methyl-1H-pyrazole (15953-45-4)

Guidance literature:

With sodium ethanolate; In ethanol; at 20 ℃; for 0.5h; Product distribution / selectivity;

Reference yield: 17.0%

1,2-dihydro-5-methyl-3H-pyrazol-3-one (4344-87-0) → 3-chloro-5-methyl-1H-pyrazole (15953-45-4)

Guidance literature:

With trichlorophosphate; at 160 ℃;

upstream raw materials:

3-methyl-2-pyrazoline-5-one

1,2-dihydro-5-methyl-3H-pyrazol-3-one

5-chloro-1,3-dimethyl-pyrazole

5-chloro-1-(2-chlorobenzenesulfonyl)-3-methylpyrazole

Downstream raw materials:

5-chloro-1H-pyrazole-3-carboxylic acid

3-chloro-1,5-dimethyl-1H-pyrazole

5-chloro-1,3-dimethyl-pyrazole

1-benzyl-5-chloro-3-methyl-1H-pyrazole

Refernces

• 1、 Pelcman, Benjamin,Sanin, Andrei,Nilsson, Peter,No, Kiyo,Schaal, Wesley,?hrman, Sara,Krog-Jensen, Christian,Forsell, Pontus,Hallberg, Anders,Larhed, Mats,Boesen, Thomas,Kromann, Hasse,Vogensen, Stine Byskov,Groth, Thomas,Claesson, Hans-Erik. "3-Substituted pyrazoles and 4-substituted triazoles as inhibitors of human 15-lipoxygenase-1". . p. 3024 - 3029. Retrieved 2015/06/22.
• 2、 -. "PYRAZOLES USEFUL IN THE TREATMENT OF INFLAMMATION". Page/Page column 50. . Retrieved 2008/06/13.