4-Ethynylpyridine

Base Information

• Chemical Name: 4-Ethynylpyridine
• CAS No.: 2510-22-7
• Molecular Formula: C7H5 N
• Molecular Weight: 103.123
• Hs Code.: 2933399090
• Mol file: 2510-22-7.mol

Synonyms:(Pyridin-4-yl)acetylene;4-Ethynylpyridine; 4-Pyridylacetylene; 4-Pyridylethyne

Chemical Property of 4-Ethynylpyridine

Chemical Property:

• Vapor Pressure: 1.94mmHg at 25°C
• Melting Point: 98 °C
• Boiling Point: 170.5oC at 760 mmHg
• PKA: 4.16±0.10(Predicted)
• Flash Point: 57.5oC
• PSA: 12.89000
• Density: 1.02g/cm3
• LogP: 1.06290
• Storage Temp.: Freezer
• Solubility.: almost transparency in Acetone

Purity/Quality:

98%,99%, ^*data from raw suppliers

4-Ethynylpyridine >98.0%(GC)(T) ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37/39-36

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-Ethynylpyridine

There total 26 articles about 4-Ethynylpyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

4-(2-(trimethylsilyl)ethynyl)pyridine (133810-35-2) → 4-pyridylacetylene (2510-22-7)

Guidance literature:

With potassium carbonate; In methanol; at 20 ℃; for 2h; Inert atmosphere;

DOI:10.1021/acs.cgd.8b01140

Reference yield: 90.0%

2-methyl-4-(pyridin-4-yl)but-3-yn-2-ol (55384-91-3) → 4-pyridylacetylene (2510-22-7)

Guidance literature:

With sodium hydroxide; In toluene; for 2h; Heating;

Reference yield: 88.0%

4-(1′-bromoethenyl)pyridine (241481-87-8) → 4-pyridylacetylene (2510-22-7)

Guidance literature:

With sodium amide; In diethyl ether; ammonia; at -78 - -30 ℃; 2 h, reflux;

DOI:10.1016/S0040-4039(99)01019-9

upstream raw materials:

2-methyl-4-(pyridin-4-yl)but-3-yn-2-ol

4-bromopyridin

trimethylsilylacetylene

1,1,3,3-tetraphenyl-1-propene

Downstream raw materials:

6-Chloro-4-cyclopropyl-1-(4-methoxy-benzyl)-4-pyridin-4-ylethynyl-3,4-dihydro-1H-quinazolin-2-one

1,4-bis(pyridine-4-ylethynyl)benzene

4-(1,1-diphenylethyl)pyridine

[Pt(η2-HCCC5H4N-4)(PPh3)2]

Refernces

• 1、 Bartual-Murgui, Carlos,Salmon, Lionel,Akou, Amal,Ortega-Villar, Norma A.,Shepherd, Helena J.,Munoz, M. Carmen,Molnar, Gabor,Real, Jose Antonio,Bousseksou, Azzedine. "Synergetic effect of host-guest chemistry and spin crossover in 3D hofmann-like metal-organic frameworks [Fe(bpac)M(CN)4] (M=Pt, Pd, Ni)". . p. 507 - 516. Retrieved 2012.
• 2、 Aguiló, Elisabet,Gavara, Raquel,Baucells, Clara,Guitart, Marta,Lima, Jo?o Carlos,Llorca, Jordi,Rodríguez, Laura. "Tuning supramolecular aurophilic structures: The effect of counterion, positive charge and solvent". . p. 7328 - 7339. Retrieved 2016.
• 3、 Keeley,ábrányi-Balogh,Keseru. "Design and characterization of a heterocyclic electrophilic fragment library for the discovery of cysteine-targeted covalent inhibitors". supporting information. p. 263 - 267. Retrieved 2019/03/05.
• 4、 -. "INHIBITORS FOR THE Β-CATENIN / T-CELL FACTOR PROTEIN–PROTEIN INTERACTION". Page/Page column 37; 38. . Retrieved 2019/10/23.