1-(3-fluoro-4-methoxybenzyl)-7-(2-fluoroethoxy)-6-methoxyisoquinoline oxalate

Base Information

• Chemical Name: 1-(3-fluoro-4-methoxybenzyl)-7-(2-fluoroethoxy)-6-methoxyisoquinoline oxalate
• CAS No.: 1335093-58-7
• Molecular Formula: C₂H₂O₄*C₂₀H₁₉F₂NO₃
• Molecular Weight: 449.408
• Mol file: 1335093-58-7.mol

Synonyms:1-(3-fluoro-4-methoxybenzyl)-7-(2-fluoroethoxy)-6-methoxyisoquinoline oxalate

Chemical Property of 1-(3-fluoro-4-methoxybenzyl)-7-(2-fluoroethoxy)-6-methoxyisoquinoline oxalate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(3-fluoro-4-methoxybenzyl)-7-(2-fluoroethoxy)-6-methoxyisoquinoline oxalate

There total 7 articles about 1-(3-fluoro-4-methoxybenzyl)-7-(2-fluoroethoxy)-6-methoxyisoquinoline oxalate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-(4-fluoro-3-methoxybenzyl)-7-(2-fluoroethoxy)-6-methoxyisoquinoline (1335093-40-7) + oxalic acid (144-62-7,97993-78-7) → 1-(3-fluoro-4-methoxybenzyl)-7-(2-fluoroethoxy)-6-methoxyisoquinoline oxalate (1335093-58-7)

Guidance literature:

In methanol; ethyl acetate; at 20 ℃; for 1h; Inert atmosphere;

DOI:10.1016/j.ejmech.2011.05.072

Reference yield:

4-(2-fluoroethoxy)-3-methoxybenzaldehyde (914394-64-2) → 1-(3-fluoro-4-methoxybenzyl)-7-(2-fluoroethoxy)-6-methoxyisoquinoline oxalate (1335093-58-7)

Guidance literature:

Multi-step reaction with 6 steps

1.1: ammonium acetate; acetic acid / 0.5 h / Reflux; Inert atmosphere

2.1: tetrahydrofuran; methanol / 20 °C / Inert atmosphere

2.2: Inert atmosphere

3.1: lithium aluminium tetrahydride / tetrahydrofuran / Reflux; Inert atmosphere

4.1: 1,1'-carbonyldiimidazole / dichloromethane / 2 h / 20 °C / Inert atmosphere

4.2: Inert atmosphere

5.1: trichlorophosphate / acetonitrile / 0.5 h / Reflux; Inert atmosphere

6.1: methanol; ethyl acetate / 1 h / 20 °C / Inert atmosphere

With lithium aluminium tetrahydride; ammonium acetate; acetic acid; 1,1'-carbonyldiimidazole; trichlorophosphate; In tetrahydrofuran; methanol; dichloromethane; ethyl acetate; acetonitrile;

DOI:10.1016/j.ejmech.2011.05.072

Reference yield:

2-(3-fluoro-4-methoxyphenyl)-N-(2-(4-(2-fluoroethoxy)-3-methoxyphenyl)-2-methoxyethyl)acetamide (1335093-75-8) → 1-(3-fluoro-4-methoxybenzyl)-7-(2-fluoroethoxy)-6-methoxyisoquinoline oxalate (1335093-58-7)

Guidance literature:

Multi-step reaction with 2 steps

1: trichlorophosphate / acetonitrile / 0.5 h / Reflux; Inert atmosphere

2: methanol; ethyl acetate / 1 h / 20 °C / Inert atmosphere

With trichlorophosphate; In methanol; ethyl acetate; acetonitrile;

DOI:10.1016/j.ejmech.2011.05.072

upstream raw materials:

4-(2-fluoroethoxy)-3-methoxybenzaldehyde

2-(3-fluoro-4-methoxyphenyl)-N-(2-(4-(2-fluoroethoxy)-3-methoxyphenyl)-2-methoxyethyl)acetamide

(E)-1-(2-fluoroethoxy)-2-methoxy-4-(2-nitrovinyl)benzene

1-(2-fluoroethoxy)-2-methoxy-4-(1-methoxy-2-nitroethyl)benzene

Refernces