3-Amino-4-cyclopropyl-1H-pyrazole

Base Information

• Chemical Name: 3-Amino-4-cyclopropyl-1H-pyrazole
• CAS No.: 673475-74-6
• Molecular Formula: C₆H₉N₃
• Molecular Weight: 123.158
• Hs Code.: 2933199090
• Mol file: 673475-74-6.mol

Synonyms:3-Amino-4-cyclopropyl-1H-pyrazole;

Chemical Property of 3-Amino-4-cyclopropyl-1H-pyrazole

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.694
• Boiling Point: 320.668 °C at 760 mmHg
• Flash Point: 173.723 °C
• PSA: 54.70000
• Density: 1.35 g/cm³
• LogP: 1.45050
• Storage Temp.: 2-8°C(protect from light)

Purity/Quality:

90.0%Min ^*data from raw suppliers

4-Cyclopropyl-1H-pyrazol-3-amine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-Amino-4-cyclopropyl-1H-pyrazole

There total 5 articles about 3-Amino-4-cyclopropyl-1H-pyrazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

2-cyclopropyl-3-oxo-propionitrile (256376-79-1) → 4-cyclopropyl-2H-pyrazol-3-ylamine (673475-74-6)

Guidance literature:

With hydrazine hydrate; acetic acid; In ethanol; Reflux;

DOI:10.1021/jm701397k

Reference yield: 18.0%

2-cyclopropylacetonitrile (6542-60-5) + formic acid ethyl ester (109-94-4) → 4-cyclopropyl-2H-pyrazol-3-ylamine (673475-74-6)

Guidance literature:

2-cyclopropylacetonitrile; formic acid ethyl ester; With sodium; In diethyl ether; at 20 ℃; for 48h; Industry scale; Cooling with ice;

With acetic acid; In diethyl ether; at 10 - 12 ℃;

With hydrazine; In tetrahydrofuran; for 2h; Reflux;

Reference yield:

2-cyclopropylacetonitrile (6542-60-5) → 4-cyclopropyl-2H-pyrazol-3-ylamine (673475-74-6)

Guidance literature:

2-cyclopropylacetonitrile; With sodium; formic acid ethyl ester; In diethyl ether; at 20 ℃; for 97h;

With acetic acid; at 10 - 15 ℃; for 0.5h;

upstream raw materials:

2-cyclopropylacetonitrile

2-cyclopropyl-3-oxo-propionitrile

formic acid ethyl ester

acetic acid

Refernces

• 1、 -. "INDOLE AHR INHIBITORS AND USES THEREOF". . . Retrieved 2018/11/22.
• 2、 Frey, Robin R.,Curtin, Michael L.,Albert, Daniel H.,Glaser, Keith B.,Pease, Lori J.,Soni, Niru B.,Bouska, Jennifer J.,Reuter, David,Stewart, Kent D.,Marcotte, Patrick,Bukofzer, Gail,Li, Junling,Davidsen, Steven K.,Michaelides, Michael R.. "7-Aminopyrazolo[1,5-a]pyrimidines as potent multitargeted receptor tyrosine kinase inhibitors". supporting information; experimental part. p. 3777 - 3787. Retrieved 2009/04/07.