Ethyl 2-(morpholin-2-yl)acetate

Base Information

• Chemical Name: Ethyl 2-(morpholin-2-yl)acetate
• CAS No.: 503601-25-0
• Molecular Formula: C8H15 N O3
• Molecular Weight: 173.21
• Hs Code.: 2934999090
• Mol file: 503601-25-0.mol

Synonyms:MORPHOLIN-2-YL-ACETIC ACID ETHYL ESTER;ETHYL 2-(MORPHOLIN-2-YL)ACETATE

Chemical Property of Ethyl 2-(morpholin-2-yl)acetate

Chemical Property:

• Boiling Point: 244.4±15.0 °C(Predicted)
• PKA: 8.53±0.40(Predicted)
• PSA: 47.56000
• Density: 1.033±0.06 g/cm3(Predicted)
• LogP: 0.25680
• Storage Temp.: 2-8°C(protect from light)

Purity/Quality:

98%min ^*data from raw suppliers

Morpholin-2-yl-aceticacidethylester 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Ethyl 2-(morpholin-2-yl)acetate

There total 6 articles about Ethyl 2-(morpholin-2-yl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.25%

ethyl 4-(phenylmethyl)-2-morpholineacetate (73933-19-4) → (±)-ethyl 2-(morpholin-2-yl)acetate (503601-25-0)

Guidance literature:

With palladium on activated charcoal; hydrogen; In methanol; at 20 ℃; for 10h; under 2585.81 Torr;

Reference yield:

(E)-4-(2-Hydroxy-ethylamino)-but-2-enoic acid ethyl ester → (±)-ethyl 2-(morpholin-2-yl)acetate (503601-25-0)

Guidance literature:

With 1,8-diazabicyclo[5.4.0]undec-7-ene; In toluene; Heating;

DOI:10.1016/S0960-894X(96)00267-3

Reference yield:

4-bromo-trans-crotonic acid ethyl ester (37746-78-4) → (±)-ethyl 2-(morpholin-2-yl)acetate (503601-25-0)

Guidance literature:

Multi-step reaction with 2 steps

1: Huenig's base / CH₂Cl₂ / 24 h / Ambient temperature

2: DBU / toluene / Heating

With 1,8-diazabicyclo[5.4.0]undec-7-ene; N-ethyl-N,N-diisopropylamine; In dichloromethane; toluene;

DOI:10.1016/S0960-894X(96)00267-3

upstream raw materials:

4-bromo-trans-crotonic acid ethyl ester

ethyl 4-(phenylmethyl)-2-morpholineacetate

Downstream raw materials:

2-(morpholin-2-yl)acetic acid hydrochloride

WYE-114152

1-(3-methoxyphenyl)-3-{2-[(2R)-morpholin-2-yl]ethyl}-1,3-dihydro-2,1,3-benzothiadiazole 2,2-dioxide

1-(4-fluorophenyl)-3-{2-[(2R)-morpholin-2-yl]ethyl}-1,3-dihydro-2,1,3-benzothiadiazole 2,2-dioxide

Refernces

• 1、 -. "PYRIDYL DERIVATIVES AS BROMODOMAIN INHIBITORS". Page/Page column 40. . Retrieved 2017/11/04.
• 2、 O'Neill, David J.,Adedoyin, Adedayo,Bray, Jenifer A.,Deecher, Darlene C.,Fensome, Andrew,Goldberg, Joel A.,Harrison, Jim,Leventhal, Liza,Mann, Charles,Mark, Lilly,Nogle, Lisa,Sullivan, Nicole R.,Spangler, Taylor B.,Terefenko, Eugene A.,Trybulski, Eugene J.,Uveges, Albert J.,Vu, An,Whiteside, Garth T.,Zhang, Puwen. "Discovery of novel selective norepinephrine inhibitors: 1-(2-morpholin-2-ylethyl)-3-aryl-1,3-dihydro-2,1,3-benzothiadiazole 2,2-dioxides (WYE-114152)". supporting information; experimental part. p. 6824 - 6831. Retrieved 2011/12/04.