2-AMINO-6-CHLOROBENZONITRILE

Base Information

• Chemical Name: 2-AMINO-6-CHLOROBENZONITRILE
• CAS No.: 147249-41-0
• Molecular Formula: C7H4Cl2N2
• Molecular Weight: 187.028
• Hs Code.: 2926909090
• Mol file: 147249-41-0.mol

Synonyms:6-Amino-2,3-dichlorobenzonitrile;

Chemical Property of 2-AMINO-6-CHLOROBENZONITRILE

Chemical Property:

• Vapor Pressure: 0.000208mmHg at 25°C
• Melting Point: 135℃
• Refractive Index: 1.609
• Boiling Point: 342.95 °C at 760 mmHg
• PKA: 0.12±0.10(Predicted)
• Flash Point: 161.211 °C
• PSA: 49.81000
• Density: 1.485 g/cm³
• LogP: 2.37508

Purity/Quality:

98%min ^*data from raw suppliers

6-Amino-2,3-dichlorobenzonitrile ^*data from reagent suppliers

Safty Information:

• Pictogram(s): R20/21/22:; R36/37/38:
• Hazard Codes: Xn:Harmful
• Statements: R20/21/22:; R36/37/38:
• Safety Statements: S22:; S26:; S36/37/39:

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-AMINO-6-CHLOROBENZONITRILE

There total 1 articles about 2-AMINO-6-CHLOROBENZONITRILE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

2,3-dichloro-6-nitrobenzonitrile (2112-22-3) → 2,3-dichloro-6-aminobenzonitrile (147249-41-0)

Guidance literature:

With hydrogenchloride; tin(ll) chloride; at 75 - 81 ℃;

DOI:10.1002/prac.199633801129

Reference yield: 72.0%

2,3-dichloro-6-aminobenzonitrile (147249-41-0) → 6-amino-2,3-dichlorobenzylamine (147249-42-1)

Guidance literature:

With potassium borohydride; trifluoroacetic acid; In tetrahydrofuran; at 20 ℃; for 3h;

DOI:10.1016/j.bmcl.2007.10.080

Reference yield: 70.0%

2,3-dichloro-6-aminobenzonitrile (147249-41-0) → 2,3-dichloro-6-aminobenzylamine dihydrochloride

Guidance literature:

2,3-dichloro-6-aminobenzonitrile; With lithium aluminium tetrahydride; In diethyl ether; at 25 - 34 ℃; for 3h;

With hydrogenchloride; In isopropyl alcohol;

upstream raw materials:

2,3-dichloro-6-nitrobenzonitrile

Downstream raw materials:

6-amino-2,3-dichlorobenzylamine

Refernces

• 1、 Peters, Jens-Uwe,Luebbers, Thomas,Alanine, Alexander,Kolczewski, Sabine,Blasco, Francesca,Steward, Lucinda. "Cyclic guanidines as dual 5-HT5A/5-HT7 receptor ligands: Structure-activity relationship elucidation". . p. 256 - 261. Retrieved 2008/12/23.