6''-AMINO-1,2,3,4-TETRAHYDROQUINOLINE

Base Information

• Chemical Name: 6''-AMINO-1,2,3,4-TETRAHYDROQUINOLINE
• CAS No.: 103796-41-4
• Molecular Formula: C9H12N2
• Molecular Weight: 148.208
• Hs Code.: 2933499090
• Mol file: 103796-41-4.mol

Synonyms:Quinoline,6-amino-1,2,3,4-tetrahydro- (6CI);6-Amino-1,2,3,4-tetrahydroquinoline;

Chemical Property of 6''-AMINO-1,2,3,4-TETRAHYDROQUINOLINE

Chemical Property:

• Melting Point: 95-97 °C
• Boiling Point: 339.1 °C at 760 mmHg
• PKA: 7.05±0.20(Predicted)
• Flash Point: 186.4 °C
• PSA: 38.05000
• Density: 1.101 g/cm³
• LogP: 2.34610

Purity/Quality:

99% ^*data from raw suppliers

1,2,3,4-Tetrahydro-quinolin-6-ylamine 96% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6''-AMINO-1,2,3,4-TETRAHYDROQUINOLINE

There total 10 articles about 6''-AMINO-1,2,3,4-TETRAHYDROQUINOLINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.3%

6-nitroquinoline (613-50-3) → 6-amino-1,2,3,4-tetrahydroquinoline (103796-41-4)

Guidance literature:

With Pd/Al₂O₃; hydrogen; In tetrahydrofuran; at 90 ℃; under 22502.3 Torr; Flow reactor;

DOI:10.1021/acs.oprd.1c00164

Reference yield: 96.0%

6-aminoquinoline (580-15-4) → 6-amino-1,2,3,4-tetrahydroquinoline (103796-41-4)

Guidance literature:

With tetrahydroxyborate; water; at 80 ℃; for 0.166667h;

DOI:10.1002/chem.201604503

Reference yield:

1-(1,2,3,4-tetrahydro-[6]quinolyl)-ethanone oxime → 6-amino-1,2,3,4-tetrahydroquinoline (103796-41-4)

Guidance literature:

With sulfuric acid;

DOI:10.1002/hlca.19520350718

upstream raw materials:

6-aminoquinoline

6-nitroquinoline

6-nitro-1,2,3,4-tetrahydroquinoline

hydrogenchloride

Downstream raw materials:

Quinoline-6-carboxylic acid

6-aminoquinoline

6-(acetylamino)-7-nitro-N-<6-<(tert-butyldiphenylsilyloxy)methyl>-2-naphthobenzyl>-1,2,3,4-tetrahydroquinoline

6-(acetylamino)-7-nitro-N-<4-<sulfonyl>benzyl>-1,2,3,4-tetrahydroquinoline

Refernces

• 1、 Vermaak, Vincent,Vosloo, Hermanus C. M.,Swarts, Andrew J.. "Fast and Efficient Nickel(II)-catalysed Transfer Hydrogenation of Quinolines with Ammonia Borane". . p. 5788 - 5793. Retrieved 2020.
• 2、 Ji, Yi-Gang,Wei, Kai,Liu, Teng,Wu, Lei,Zhang, Wei-Hua. "“Naked” Iridium(IV) Oxide Nanoparticles as Expedient and Robust Catalysts for Hydrogenation of Nitrogen Heterocycles: Remarkable Vicinal Substitution Effect and Recyclability". . p. 933 - 940. Retrieved 2017.
• 3、 Chen, Xingkun,Duan, Xiaonan,Wang, Xuepeng,Zhang, Jisong. "Continuous and Selective Hydrogenation of Heterocyclic Nitroaromatics in a Micropacked Bed Reactor". . p. 2100 - 2109. Retrieved 2021.
• 4、 Cao, Zhe,He, Zhen-Hong,Liu, Zhao-Tie,Wang, Dan,Wang, Junlei,Wang, Kuan,Wang, Weitao,Yang, Yang,Zhang, Rong-Rong. "Efficient and selective hydrogenation of quinolines over FeNiCu/MCM-41 catalyst at low temperature: Synergism of Fe-Ni and Ni-Cu alloys". . . Retrieved 2022/03/03.