3,5-Dibenzyloxy terbutalline

Base Information

• Chemical Name: 3,5-Dibenzyloxy terbutalline
• CAS No.: 28924-25-6
• Molecular Formula: C26H31 N O3
• Molecular Weight: 405.537
• Mol file: 28924-25-6.mol

Synonyms:Benzylalcohol, 3,5-bis(benzyloxy)-a-[(tert-butylamino)methyl]- (8CI); 1-[3,5-Bis(benzyloxy)phenyl]-2-(tert-butylamino)ethanol

Chemical Property of 3,5-Dibenzyloxy terbutalline

Chemical Property:

• Melting Point: 124-126?C
• PSA: 50.72000
• Density: 1.111
• LogP: 5.65700
• Storage Temp.: Refrigerator
• Solubility.: Chloroform

Purity/Quality:

98%min ^*data from raw suppliers

Terbutaline3,5-DibenzylEther ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Intermediate for the preparation of Terbutaline Intermediate for the preparation of Terbutaline.

Technology Process of 3,5-Dibenzyloxy terbutalline

There total 11 articles about 3,5-Dibenzyloxy terbutalline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

1-[3,5-bis(benzyloxy)phenyl]-2-bromoethanol + tert-butylamine (75-64-9) → 1-[3,5-bis(benzyloxy)phenyl]-2-(tert-butylamino)ethanol (28924-25-6)

Guidance literature:

In isopropyl alcohol; at 20 - 85 ℃; for 6.5h; Solvent; Temperature;

Reference yield: 65.0%

3,5-dibenzyloxyphenylglyoxal (50841-49-1) + tert-butylamine (75-64-9) → 1-[3,5-bis(benzyloxy)phenyl]-2-(tert-butylamino)ethanol (28924-25-6)

Guidance literature:

3,5-dibenzyloxyphenylglyoxal; tert-butylamine; With ethanol; at 80 ℃; for 4h;

With potassium borohydride; ethanol; at 40 ℃; for 1h; Temperature;

Reference yield:

C26H27NO3 → 1-[3,5-bis(benzyloxy)phenyl]-2-(tert-butylamino)ethanol (28924-25-6)

Guidance literature:

With sodium tetrahydroborate; In methanol; water; at 0 - 25 ℃;

upstream raw materials:

tert-butylamine

benzyl bromide

3,5-dihydroxyacetophenone

3,5-dibenzyloxyacetophenone

Downstream raw materials:

terbutaline

terbutaline hemisulfate

Refernces

• 1、 -. "Preparation method of terbutaline sulfate (by machine translation)". . . Retrieved 2020/04/17.
• 2、 -. "A synthesis method of terbutaline sulfate (by machine translation)". Paragraph 0054; 0062; 0063. . Retrieved 2018/10/04.