1-Allylcyclopropane-1-sulfonyl chloride

Base Information

• Chemical Name: 1-Allylcyclopropane-1-sulfonyl chloride
• CAS No.: 923032-59-1
• Molecular Formula: C₆H₉ClO₂S
• Molecular Weight: 180.655
• Mol file: 923032-59-1.mol

Synonyms:1-Allylcyclopropanesulfonylchloride;Cyclopropanesulfonylchloride, 1-(2-propen-1-yl)-;

Chemical Property of 1-Allylcyclopropane-1-sulfonyl chloride

Chemical Property:

• Appearance/Colour: yellow oil
• Refractive Index: 1.515
• Boiling Point: 229.2 °C at 760 mmHg
• Flash Point: 92.4 °C
• PSA: 42.52000
• Density: 1.32 g/cm³
• LogP: 2.74450
• Storage Temp.: Hygroscopic, Refrigerator, Under Inert Atmosphere
• Solubility.: Chlroform

Purity/Quality:

99% ^*data from raw suppliers

1-Allylcyclopropane-1-sulfonyl Chloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: As a MEK inhibitors, 1-Allylcyclopropane-1-sulfonyl chloride can be useful in the treatment of cancer and other hyperproliferative diseases.

Technology Process of 1-Allylcyclopropane-1-sulfonyl chloride

There total 2 articles about 1-Allylcyclopropane-1-sulfonyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

potassium 1-allylcyclopropane-1-sulfonate (923032-57-9) → 1-allylcyclopropane-1-sulfonyl chloride (923032-59-1)

Guidance literature:

With thionyl chloride; N,N-dimethyl-formamide; for 16h; Heating / reflux;

Reference yield:

butyl 1-allylcyclopropane-1-sulfonate (923032-56-8) → 1-allylcyclopropane-1-sulfonyl chloride (923032-59-1)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium thioacyanate / 1,2-dimethoxyethane; water / 16 h / Reflux

2: thionyl chloride / N,N-dimethyl-formamide / 16 h / 60 °C / Reflux

With thionyl chloride; potassium thioacyanate; In 1,2-dimethoxyethane; water; N,N-dimethyl-formamide;

upstream raw materials:

potassium 1-allylcyclopropane-1-sulfonate

butyl 1-allylcyclopropane-1-sulfonate

Refernces

• 1、 -. "COMBINATIONS OF MEK INHIBITORS AND RAF KINASE INHIBITORS AND USES THEREOF". . . Retrieved 2012/06/16.
• 2、 -. "N-(ARYLAMINO)-SULFONAMIDE INHIBITORS OF MEK". Page/Page column 52. . Retrieved 2008/06/13.