tert-butyl 3-aminopyrazole-l- carboxylate

Base Information

• Chemical Name: tert-butyl 3-aminopyrazole-l- carboxylate
• CAS No.: 863504-84-1
• Molecular Formula: C8H13 N3 O2
• Molecular Weight: 183.21
• Hs Code.: 2933199090
• Mol file: 863504-84-1.mol

Synonyms:1,1-Dimethylethyl3-amino-1H-pyrazole-1-carboxylate;3-Aminopyrazole-1-carboxylic acid tert-butylester;tert-Butyl 3-amino-1H-pyrazole-1-carboxylate;tert-Butyl3-aminopyrazole-1-carboxylate;

Chemical Property of tert-butyl 3-aminopyrazole-l- carboxylate

Chemical Property:

• Refractive Index: 1.545
• Boiling Point: 307 ºC
• PKA: 2.76±0.10(Predicted)
• Flash Point: 139 ºC
• PSA: 70.14000
• Density: 1.20
• LogP: 1.82970
• Storage Temp.: 2-8°C(protect from light)

Purity/Quality:

98%,99%, ^*data from raw suppliers

tert-Butyl3-amino-1H-pyrazole-1-carboxylate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of tert-butyl 3-aminopyrazole-l- carboxylate

There total 6 articles about tert-butyl 3-aminopyrazole-l- carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

3-aminopyrazole (1820-80-0,916420-28-5) + di-tert-butyl dicarbonate (24424-99-5) → 3-aminopyrazole-1-carboxylic acid tert-butyl ester (863504-84-1)

Guidance literature:

With dmap; triethylamine; In 1,4-dioxane; at 20 ℃; for 4h;

Reference yield: 57.0%

3-aminopyrazole (1820-80-0,916420-28-5) + di-tert-butyl dicarbonate (24424-99-5) → 3-aminopyrazole-1-carboxylic acid tert-butyl ester (863504-84-1) + tert-butyl 5-amino-1H-pyrazole-1-carboxylate (1003011-02-6)

Guidance literature:

With triethylamine; In 1,4-dioxane; at 25 ℃; for 4h;

Reference yield: 52.0%

5-cyclopropyl-2H-pyrazol-3-ylamine (175137-46-9) + di-tert-butyl dicarbonate (24424-99-5) → 3-aminopyrazole-1-carboxylic acid tert-butyl ester (863504-84-1)

Guidance literature:

With triethylamine; In 1,4-dioxane; at 25 ℃; for 2h;

upstream raw materials:

3-aminopyrazole

di-tert-butyl dicarbonate

5-cyclopropyl-2H-pyrazol-3-ylamine

Downstream raw materials:

1,1-dimethylethyl 3-{[(3-hydroxy-5-{[(1S)-1-methyl-2-(methyloxy)ethyl]oxy}phenyl)carbonyl]amino}-1H-pyrazole-1-carboxylate

tert-butyl 3-[(3-hydroxy-5-{(1S)-1-methyl-2-[(triisopropylsilyl)oxy]ethoxy}benzoyl)amino]-1H-pyrazole-1-carboxylate

tert-butyl 3-({3-[4-(ethoxycarbonyl)phenoxy]-5-[(1S)-2-methoxy-1-methylethoxy]benzoyl}amino)-1H-pyrazole-1-carboxylate

tert-butyl 3-{[3-({5-[(cyclopropylmethyl)(tetrahydro-2H-pyran-4-ylcarbonyl)amino]pyrazin-2-yl}oxy)-5-{[(2S)-1-methoxypropan-2-yl]oxy}benzoyl]amino}-1H-pyrazole-1-carboxylate

Refernces

• 1、 -. "SPIRO THREE-MEMBERED RING, SPIRO FIVE-MEMBERED RING PEPTIDE DEFORMYLASE INHIBITOR AND USE THEREOF IN ANTIBACTERIA AND ANTI-TUMOUR.". Paragraph 0065. . Retrieved 2019/05/22.
• 2、 Rana, Sandeep,Sonawane, Yogesh A.,Taylor, Margaret A.,Kizhake, Smitha,Zahid, Muhammad,Natarajan, Amarnath. "Synthesis of aminopyrazole analogs and their evaluation as CDK inhibitors for cancer therapy". supporting information. p. 3736 - 3740. Retrieved 2018/10/24.