Esreboxetine succinate

Base Information

• Chemical Name: Esreboxetine succinate
• CAS No.: 635724-55-9
• Molecular Formula: C₄H₆O₄*C₁₉H₂₃NO₃
• Molecular Weight: 431.486
• Mol file: 635724-55-9.mol

Synonyms:(2S)-2-[(S)-(2-ethoxyphenoxy)(phenyl)methyl]morpholine butanedioate (1:1);morpholine, 2-[(S)-(2-ethoxyphenoxy)phenylmethyl]-, (2S)-, butanedioate (1:1);(S,S)-reboxetine succinate;(2S)-2-[(S)-(2-Ethoxyphenoxy)(phenyl)methyl]morpholine succinate (1:1);

Chemical Property of Esreboxetine succinate

Chemical Property:

• Melting Point: 149-152 °C
• PSA: 114.32000
• LogP: 3.45840

Purity/Quality:

98%Min ^*data from raw suppliers

(S,S)-REBOXETINE SUCCINATE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Esreboxetine succinate

There total 32 articles about Esreboxetine succinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

succinic acid (110-15-6) + (S,S)-reboxetine (71620-89-8,71621-36-8,93851-86-6,98769-81-4,98769-83-6,98819-76-2,105017-38-7) → (2S,3S)-2-[α-(2-ethoxyphenoxy)benzyl]morpholine succinate (635724-55-9)

Guidance literature:

In isopropyl alcohol; for 1h; Reflux;

DOI:10.1002/adsc.201100398

Reference yield: 88.0%

succinic acid (110-15-6) + (S,S)-reboxetine (S)-mandelate (104968-70-9) → (2S,3S)-2-[α-(2-ethoxyphenoxy)benzyl]morpholine succinate (635724-55-9)

Guidance literature:

(S,S)-reboxetine (S)-mandelate; With sodium hydroxide; In dichloromethane; water;

succinic acid; In ethanol;

DOI:10.1021/op200181f

Reference yield: 82.0%

succinic acid (110-15-6) + 2-{[(2S,3S)-3-(2-ethoxyphenoxy)-2-hydroxy-3-phenylpropyl]amino}ethyl hydrogen sulfate (1250978-71-2) → (2S,3S)-2-[α-(2-ethoxyphenoxy)benzyl]morpholine succinate (635724-55-9)

Guidance literature:

2-{[(2S,3S)-3-(2-ethoxyphenoxy)-2-hydroxy-3-phenylpropyl]amino}ethyl hydrogen sulfate; With sodium hydroxide; In tetrahydrofuran; ethanol; at 20 ℃; for 3h; Reflux; Large scale reaction;

succinic acid; In ethanol; Large scale reaction;

DOI:10.1016/j.tetlet.2010.07.106

upstream raw materials:

succinic acid

(S,S)-reboxetine

(S,S)-reboxetine (S)-mandelate

2-{[(2S,3S)-3-(2-ethoxyphenoxy)-2-hydroxy-3-phenylpropyl]amino}ethyl hydrogen sulfate

Refernces

• 1、 Akashi, Masaya,Arai, Noriyoshi,Inoue, Tsutomu,Ohkuma, Takeshi. "Catalyst-controlled diastereoselection in the hydrogenation of heterocycloalkyl ketones". supporting information; experimental part. p. 1955 - 1960. Retrieved 2011/10/12.
• 2、 Assaf, Georges,Cansell, Gemma,Critcher, Doug,Field, Stuart,Hayes, Stewart,Mathew, Suju,Pettman, Alan. "Application of a process friendly morpholine synthesis to (S,S)-Reboxetine". experimental part. p. 5048 - 5051. Retrieved 2011/01/12.