Giripladib

Base Information

• Chemical Name: Giripladib
• CAS No.: 865200-20-0
• Molecular Formula: C₄₁H₃₆ClF₃N₂O₄S
• Molecular Weight: 745.262
• UNII: 1W10Q5H7WD
• ChEMBL ID: CHEMBL2104969
• DSSTox Substance ID: DTXSID00471130
• Metabolomics Workbench ID: 155486
• NCI Thesaurus Code: C166518
• Wikidata: Q27252970
• Mol file: 865200-20-0.mol

Synonyms:giripladib;PLA-695;Wyeth-2 compound

Chemical Property of Giripladib

Chemical Property:

• Boiling Point: 852.6±75.0 °C(Predicted)
• PKA: 4.34±0.10(Predicted)
• PSA: 96.78000
• Density: 1.29 g/cm³
• LogP: 10.95850
• XLogP3: 10
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 8
• Rotatable Bond Count: 14
• Exact Mass: 744.2036410
• Heavy Atom Count: 52
• Complexity: 1210

Purity/Quality:

98%Min ^*data from raw suppliers

Giripladib ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)C(C2=CC=CC=C2)N3C4=C(C=C(C=C4)Cl)C(=C3CCNS(=O)(=O)CC5=CC=CC=C5C(F)(F)F)CCCC6=CC=C(C=C6)C(=O)O
• Recent ClinicalTrials: Study Evaluating the Gastrointestinal Safety of PLA-695 Compared to Placebo and Naproxen
• Recent EU Clinical Trials: A MULTICENTER, RANDOMIZED, DOUBLE-BLIND COMPARISON OF 4 DOSE
• Uses: Giripladib inhibits cytosolic phospholipase A2 (cPLA2) which in turn radiosensitizes tumors in lung cancer animal models.

Technology Process of Giripladib

There total 2 articles about Giripladib which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

4-(3-{5-chloro-1-(diphenylmethyl)-2-[2-({[2-(trifluoromethyl)benzyl]sulfonyl}amino)ethyl]-1H-indol-3-yl}propyl)benzoic acid methyl ester → giripladib (865200-20-0)

Guidance literature:

4-(3-{5-chloro-1-(diphenylmethyl)-2-[2-({[2-(trifluoromethyl)benzyl]sulfonyl}amino)ethyl]-1H-indol-3-yl}propyl)benzoic acid methyl ester; With sodium hydroxide; water; In tetrahydrofuran; methanol;

With hydrogenchloride; In tetrahydrofuran; methanol; water; pH=2 - 4;

Reference yield: 88.0%

→ giripladib (865200-20-0)

Guidance literature:

Refernces

• 1、 -. "INHIBITORS OF CYTOSOLIC PHOSPHOLIPASE A2". Page/Page column 38. . Retrieved 2008/06/13.