Technology Process of 2-oxo-2-(p-tolyl)ethyl 3-(benzamido)benzoate
There total 4 articles about 2-oxo-2-(p-tolyl)ethyl 3-(benzamido)benzoate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
3-benzamidobenzoic acid;
With
caesium carbonate;
In
ethanol; water;
pH=6.5;
4-(bromoacetyl)toluene;
In
N,N-dimethyl-formamide;
for 12h;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: thionyl chloride / 16 h / 0 °C
2.1: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 16 h
3.1: water; lithium hydroxide monohydrate / tetrahydrofuran / 16 h
4.1: caesium carbonate / ethanol; water / pH 6.5
4.2: 12 h
With
thionyl chloride; lithium hydroxide monohydrate; water; benzotriazol-1-ol; caesium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine;
In
tetrahydrofuran; ethanol; dichloromethane; water;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 16 h
2.1: water; lithium hydroxide monohydrate / tetrahydrofuran / 16 h
3.1: caesium carbonate / ethanol; water / pH 6.5
3.2: 12 h
With
lithium hydroxide monohydrate; water; benzotriazol-1-ol; caesium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine;
In
tetrahydrofuran; ethanol; dichloromethane; water;