1,3-BIS(DI-TERT-BUTYLPHOSPHINO)PROPANE

Base Information

• Chemical Name: 1,3-BIS(DI-TERT-BUTYLPHOSPHINO)PROPANE
• CAS No.: 121115-33-1
• Molecular Formula: C₁₉H₄₂P₂
• Molecular Weight: 332.49
• Mol file: 121115-33-1.mol

Synonyms:Phosphine,1,3-propanediylbis[bis(1,1-dimethylethyl)- (9CI);1,3-Bis(di-tert-butylphosphinomethyl)propane;1,3-Bis-(di-tert-butylphosphino)propane

Chemical Property of 1,3-BIS(DI-TERT-BUTYLPHOSPHINO)PROPANE

Chemical Property:

• Boiling Point: 379.2±25.0 °C(Predicted)
• PSA: 27.18000
• LogP: 7.53430

Purity/Quality:

98% ^*data from raw suppliers

1,3-Bis(di-tert-butylphosphino)propane 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1,3-BIS(DI-TERT-BUTYLPHOSPHINO)PROPANE

There total 4 articles about 1,3-BIS(DI-TERT-BUTYLPHOSPHINO)PROPANE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

di-tert-butylphosphine (819-19-2) + 1,3-Dichloropropane (142-28-9) → 1,3-bis(di-tert-butylphosphino)propane (121115-33-1)

Guidance literature:

di-tert-butylphosphine; With n-butyllithium; In hexane; for 1h; Schlenk technique; Inert atmosphere;

1,3-Dichloropropane; In tetrahydrofuran; at -78 - 20 ℃; for 17.25h; Schlenk technique; Inert atmosphere;

DOI:10.1021/cs500853f

Reference yield: 62.0%

1,3-difluoropropane (462-39-5) + lithium di-tert-butylphosphide (19966-86-0) → 1,3-bis(di-tert-butylphosphino)propane (121115-33-1)

Guidance literature:

In 1,4-dioxane; at 40 ℃;

DOI:10.1016/j.tetlet.2006.12.027

Reference yield: 56.0%

1,3-dibromo-propane (109-64-8) + di-tert-butylphosphine borane → 1,3-bis(di-tert-butylphosphino)propane (121115-33-1)

Guidance literature:

di-tert-butylphosphine borane; With n-butyllithium; In tetrahydrofuran; cyclohexane; at -78 - 20 ℃; for 1h;

1,3-dibromo-propane; In tetrahydrofuran; cyclohexane; at -78 - 20 ℃;

With pyrrolidine; at 50 ℃; for 16h;

DOI:10.1021/acs.organomet.5b00517

upstream raw materials:

di-tert-butylphosphine

1,3-Dichloropropane

1,3-difluoropropane

lithium di-tert-butylphosphide

Downstream raw materials:

{Pt(dbpp)(η2-CH2CHC6H4Me-4)}

{Pt(dbpp)(η2-CH2CHC6H4Br-4)}

{Pt(dbpp)(η2-CH2CHC6H5)}

{Pt(dbpp)(η2-CH2CHC6H4Br-3)}

Refernces

• 1、 Low, Choon Heng,Nobbs, James D.,Van Meurs, Martin,Stubbs, Ludger P.,Drent, Eite,Aitipamula, Srinivasulu,Pung, Michelle H. L.. "Palladium Complexes with Bulky Diphosphine Ligands as Highly Selective Catalysts for the Synthesis of (Bio-) Adipic Acid from Pentenoic Acid Mixtures.". . p. 4281 - 4292. Retrieved 2015/09/22.
• 2、 Morris, David J.,Docherty, Gordon,Woodward, Gary,Wills, Martin. "Modification of ligand properties of phosphine ligands for C-C and C-N bond-forming reactions". . p. 949 - 953. Retrieved 2008/02/04.