(1R,3'R)-Solifenacin Succinate

Base Information

• Chemical Name: (1R,3'R)-Solifenacin Succinate
• CAS No.: 862207-70-3
• Molecular Formula: C₄H₆O₄*C₂₃H₂₆N₂O₂
• Molecular Weight: 480.561
• Mol file: 862207-70-3.mol

Synonyms:(3R)-1-azabicyclo[2.2.2]oct-3-yl (1R)-3,4-dihydro-1-phenyl-2(1H)-isoquinoline carboxylate succinate

Chemical Property of (1R,3'R)-Solifenacin Succinate

Chemical Property:

• Melting Point: 73-80°C
• Storage Temp.: Hygroscopic, -20°C Freezer, Under inert atmosphere
• Solubility.: DMSO (Slightly), Methanol (Slightly)

Purity/Quality:

98% ^*data from raw suppliers

(R,R)-SolifenacinSuccinate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Solifenacin Related Compound 3 Succinate is the R,R-enantiomer of Solifenacin Succinate (S676701), a muscarinic M3 receptor antagoinst used in treatment of urinary incontinence. (R,R)-Solifenacin Succinate is the R,R-enantiomer of Solifenacin Succinate (S676701), a muscarinic M3 receptor antagoinst used in treatment of urinary incontinence.

Technology Process of (1R,3'R)-Solifenacin Succinate

There total 2 articles about (1R,3'R)-Solifenacin Succinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

(1S)-3,4-dihydro-1-phenyl-2-(1H)-isoquinolinecarboxylic acid (3S)-1-azabicyclo[2.2.2]oct-3-yl ester (732228-02-3,180272-14-4) + (3R)-1-azabicyclo[2.2.2]oct-3-yl (1R)-3,4-dihydro-1-phenyl-2(1H)-isoquinolinecarboxylate (740780-79-4,180272-14-4) + succinic acid (110-15-6) + (S)-1-phenyl-1,2,3,4-tetrahydroisoquinoline (22990-19-8,96719-89-0,118864-75-8) + solifenacin (242478-37-1,180272-14-4) → (1S)-3,4-dihydro-1-phenyl-2-(1H)-isoquinolinecarboxylic acid (3S)-1-azabicyclo[2.2.2]oct-3-yl ester succinate (862207-71-4,1262506-09-1,242478-38-2) + (3R)-1-azabicyclo[2.2.2]oct-3-yl (1R)-3,4-dihydro-1-phenyl-2(1H)-isoquinoline carboxylate succinate (862207-70-3,1262506-09-1,242478-38-2) + 1-(S)-phenyl-1,2,3,4-tetrahydroisoquinoline succinate + solifenacin succinate (1262506-09-1,242478-38-2)

Guidance literature:

In isopropyl alcohol; at 20 ℃;

Reference yield:

succinic acid (110-15-6) + solifenacin (242478-37-1,180272-14-4) → (1S)-3,4-dihydro-1-phenyl-2-(1H)-isoquinolinecarboxylic acid (3S)-1-azabicyclo[2.2.2]oct-3-yl ester succinate (862207-71-4,1262506-09-1,242478-38-2) + (3R)-1-azabicyclo[2.2.2]oct-3-yl (1R)-3,4-dihydro-1-phenyl-2(1H)-isoquinoline carboxylate succinate (862207-70-3,1262506-09-1,242478-38-2) + solifenacin succinate (1262506-09-1,242478-38-2)

Guidance literature:

In ethanol; ethyl acetate; at 0 - 50 ℃; Product distribution / selectivity;

upstream raw materials:

succinic acid

solifenacin

(1S)-3,4-dihydro-1-phenyl-2-(1H)-isoquinolinecarboxylic acid (3S)-1-azabicyclo[2.2.2]oct-3-yl ester

(3R)-1-azabicyclo[2.2.2]oct-3-yl (1R)-3,4-dihydro-1-phenyl-2(1H)-isoquinolinecarboxylate

Refernces

• 1、 -. "COMPOSITION CONTAINING SOLIFENACIN SUCCINATE". Page/Page column 11. . Retrieved 2008/06/13.