(S)-1-phenylethyl vinylcarbamothioate

Base Information

• Chemical Name: (S)-1-phenylethyl vinylcarbamothioate
• CAS No.: 1371664-48-0
• Molecular Formula: C₁₁H₁₃NOS
• Molecular Weight: 207.296
• Mol file: 1371664-48-0.mol

Synonyms:(S)-1-phenylethyl vinylcarbamothioate

Chemical Property of (S)-1-phenylethyl vinylcarbamothioate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of (S)-1-phenylethyl vinylcarbamothioate

There total 1 articles about (S)-1-phenylethyl vinylcarbamothioate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

isocyanatoethene (3555-94-0) + (S)-1-mercapto-1-phenylethane (33877-11-1) → (S)-1-phenylethyl vinylcarbamothioate (1371664-48-0)

Guidance literature:

In dichloromethane; at 20 ℃; for 30h; Inert atmosphere;

DOI:10.1021/ja301591m

Reference yield: 100.0%

(S)-1-phenylethyl vinylcarbamothioate (1371664-48-0) + methyl iodide (74-88-4) → (S)-1-phenylethyl methyl(vinyl)carbamothioate (1371664-62-8)

Guidance literature:

With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 0 - 20 ℃; Inert atmosphere;

DOI:10.1021/ja301591m

Reference yield:

(S)-1-phenylethyl vinylcarbamothioate (1371664-48-0) → (R)-S-2-phenylbut-3-en-2-yl methylcarbamothioate (1371664-49-1)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0 - 20 °C / Inert atmosphere

2: n-butyllithium; propionic acid; diisopropylamine / tetrahydrofuran / 0.2 h / -60 - 20 °C / Inert atmosphere

With n-butyllithium; sodium hydride; propionic acid; diisopropylamine; In tetrahydrofuran; N,N-dimethyl-formamide; mineral oil;

DOI:10.1021/ja301591m

upstream raw materials:

isocyanatoethene

(S)-1-mercapto-1-phenylethane

Downstream raw materials:

(R)-S-2-phenylbut-3-en-2-yl methylcarbamothioate

(S)-1-phenylethyl methyl(vinyl)carbamothioate

Refernces