1H-Indene-1-carboxylicacid,1-amino-2,3-dihydro-,ethylester(9CI)

Base Information

• Chemical Name: 1H-Indene-1-carboxylicacid,1-amino-2,3-dihydro-,ethylester(9CI)
• CAS No.: 119511-77-2
• Molecular Formula: C₁₂H₁₅NO₂
• Molecular Weight: 205.257
• Mol file: 119511-77-2.mol

Synonyms:Ethyl1-amino-2,3-dihydro-1H-indene-1-carboxylate

Chemical Property of 1H-Indene-1-carboxylicacid,1-amino-2,3-dihydro-,ethylester(9CI)

Chemical Property:

• Melting Point: 88 °C(Solv: ethanol (64-17-5))
• Boiling Point: 297.7±40.0 °C(Predicted)
• PKA: 7.21±0.20(Predicted)
• Density: 1.148±0.06 g/cm3(Predicted)

Purity/Quality:

99% ^*data from raw suppliers

Ethyl1-amino-2,3-dihydro-1H-indene-1-carboxylate 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1H-Indene-1-carboxylicacid,1-amino-2,3-dihydro-,ethylester(9CI)

There total 3 articles about 1H-Indene-1-carboxylicacid,1-amino-2,3-dihydro-,ethylester(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

ethanol (64-17-5) + 1-amino-2,3-dihydro-1H-indene-1-carboxylic acid (3927-71-7) → ethyl 1-amino-2,3-dihydro-1H-indene-1-carboxylate (119511-77-2)

Guidance literature:

ethanol; 1-amino-2,3-dihydro-1H-indene-1-carboxylic acid; With thionyl chloride; for 4h; Heating / reflux;

With sodium hydroxide; In water; pH=9;

Reference yield: 73.0%

spiro[imidazolidine-4,1'-indan]-2,5-dione (6252-98-8) + ethanol (64-17-5) → ethyl 1-amino-2,3-dihydro-1H-indene-1-carboxylate (119511-77-2)

Guidance literature:

spiro[imidazolidine-4,1'-indan]-2,5-dione; With barium hydroxide octahydrate; water; at 150 ℃; for 72h; Sealed tube;

ethanol; With thionyl chloride; at 0 ℃; for 24h; Reflux;

Reference yield:

spiro[imidazolidine-4,1'-indan]-2,5-dione (6252-98-8) → ethyl 1-amino-2,3-dihydro-1H-indene-1-carboxylate (119511-77-2)

Guidance literature:

Multi-step reaction with 2 steps

1: barium hydroxide octahydrate / water / 72 h / 150 °C

2: thionyl chloride / 24 h / 0 °C / Reflux

With thionyl chloride; barium hydroxide octahydrate; In water;

DOI:10.1002/ejoc.201001575

upstream raw materials:

ethanol

1-amino-2,3-dihydro-1H-indene-1-carboxylic acid

spiro[imidazolidine-4,1'-indan]-2,5-dione

Downstream raw materials:

(S)-2-(2,5-dioxo-2',3'-dihydrospiro[imidazolidine-4,1'-indene]-1-yl)acetic acid

Refernces

• 1、 -. "SPIROCYCLIC HAT INHIBITORS AND METHODS FOR THEIR USE". Page/Page column 529; 540. . Retrieved 2016/04/10.
• 2、 -. "ANTI-VIRAL COMPOUNDS". Page/Page column 134. . Retrieved 2008/12/08.