[6,7-bis(2-methoxyethoxy)-4-chinazolinyl](3-ethynylphenyl)amine adipinate

Base Information

• Chemical Name: [6,7-bis(2-methoxyethoxy)-4-chinazolinyl](3-ethynylphenyl)amine adipinate
• CAS No.: 1429636-54-3
• Molecular Formula: C₆H₁₀O₄*C₂₂H₂₃N₃O₄
• Molecular Weight: 539.585
• Mol file: 1429636-54-3.mol

Synonyms:[6,7-bis(2-methoxyethoxy)-4-chinazolinyl](3-ethynylphenyl)amine adipinate

Chemical Property of [6,7-bis(2-methoxyethoxy)-4-chinazolinyl](3-ethynylphenyl)amine adipinate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of [6,7-bis(2-methoxyethoxy)-4-chinazolinyl](3-ethynylphenyl)amine adipinate

There total 2 articles about [6,7-bis(2-methoxyethoxy)-4-chinazolinyl](3-ethynylphenyl)amine adipinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

Adipic acid (124-04-9) + erlotinib hydrochloride (183319-69-9) → [6,7-bis(2-methoxyethoxy)-4-chinazolinyl](3-ethynylphenyl)amine adipinate (1429636-54-3)

Guidance literature:

erlotinib hydrochloride; With ammonium hydroxide; In water; ethyl acetate; at 50 ℃; for 0.5h;

Adipic acid; In ethanol; ethyl acetate; for 24h; Cooling with ice;

Reference yield:

Adipic acid (124-04-9) + erlotinib (183321-74-6) → [6,7-bis(2-methoxyethoxy)-4-chinazolinyl](3-ethynylphenyl)amine adipinate (1429636-54-3)

Guidance literature:

In ethanol; Reflux;

upstream raw materials:

Adipic acid

erlotinib hydrochloride

erlotinib

Refernces