Technology Process of (-)-(2S,3S)-4-(2,5-dimethoxyphenyl)-2,3-dihydroxy-2,3-O-isopropylidene-3-methylbutanal
There total 10 articles about (-)-(2S,3S)-4-(2,5-dimethoxyphenyl)-2,3-dihydroxy-2,3-O-isopropylidene-3-methylbutanal which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
sodium periodate; osmium(VIII) oxide;
In
diethyl ether; water;
for 48h;
Ambient temperature;
DOI:10.1021/jo00001a073
- Guidance literature:
-
Multi-step reaction with 8 steps
1: 95 percent / NaI / butan-2-one / 3 h / Heating
2: 95 percent / Zn, HOAc / H2O; tetrahydrofuran / 3 h / Ambient temperature
3: diethyl ether
4: 98 percent / LiAlH4 / tetrahydrofuran / Ambient temperature
5: 1) n-BuLi / 1) ether, hexane, 24h, RT, 2) ether, -78 deg C, 1h
7: Bu3SnH / AIBN / toluene / 2.5 h / Heating
8: 80 percent / OsO4, NaIO4 / diethyl ether; H2O; various solvent(s) / 48 h / Ambient temperature
With
sodium periodate; osmium(VIII) oxide; lithium aluminium tetrahydride; n-butyllithium; tri-n-butyl-tin hydride; acetic acid; sodium iodide; zinc;
2,2'-azobis(isobutyronitrile);
In
tetrahydrofuran; diethyl ether; water; toluene; butanone;
DOI:10.1021/jo00001a073
- Guidance literature:
-
Multi-step reaction with 6 steps
1: diethyl ether
2: 98 percent / LiAlH4 / tetrahydrofuran / Ambient temperature
3: 1) n-BuLi / 1) ether, hexane, 24h, RT, 2) ether, -78 deg C, 1h
5: Bu3SnH / AIBN / toluene / 2.5 h / Heating
6: 80 percent / OsO4, NaIO4 / diethyl ether; H2O; various solvent(s) / 48 h / Ambient temperature
With
sodium periodate; osmium(VIII) oxide; lithium aluminium tetrahydride; n-butyllithium; tri-n-butyl-tin hydride;
2,2'-azobis(isobutyronitrile);
In
tetrahydrofuran; diethyl ether; water; toluene;
DOI:10.1021/jo00001a073