(-)-(R)-1-bromo-2,2-diphenylcyclopropanecarboxylic acid

Base Information

• Chemical Name: (-)-(R)-1-bromo-2,2-diphenylcyclopropanecarboxylic acid
• CAS No.: 13398-56-6
• Molecular Formula: C₁₆H₁₃BrO₂
• Molecular Weight: 317.182
• Mol file: 13398-56-6.mol

Synonyms:(-)-(R)-1-bromo-2,2-diphenylcyclopropanecarboxylic acid

Chemical Property of (-)-(R)-1-bromo-2,2-diphenylcyclopropanecarboxylic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (-)-(R)-1-bromo-2,2-diphenylcyclopropanecarboxylic acid

There total 9 articles about (-)-(R)-1-bromo-2,2-diphenylcyclopropanecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

1-bromo-2,2-diphenylcyclopropanecarboxylic acid (19481-83-5) → (S)-(+)-1-bromo-2,2-diphenyl-cyclopropylcarboxylic acid (83198-34-9) + (-)-(R)-1-bromo-2,2-diphenylcyclopropanecarboxylic acid (13398-56-6)

Guidance literature:

With brucine; In methanol; acetone; at 60 ℃; for 0.5h;

DOI:10.1021/ol070149g

Reference yield:

C16H13BrO2*C19H22N2O → (-)-(R)-1-bromo-2,2-diphenylcyclopropanecarboxylic acid (13398-56-6)

Guidance literature:

With hydrogenchloride; In water; ethyl acetate; pH=2;

DOI:10.1016/j.tetasy.2014.10.017

Reference yield:

1-Brom-2,2-diphenylcyclopropancarbonsaeure-methylester (13398-28-2) → (-)-(R)-1-bromo-2,2-diphenylcyclopropanecarboxylic acid (13398-56-6)

Guidance literature:

Multi-step reaction with 2 steps

1: aq. KOH / methanol

With potassium hydroxide; In methanol;

DOI:10.1021/ja01472a023

upstream raw materials:

(R)-1-Bromo-2,2-diphenyl-cyclopropanecarboperoxoic acid tert-butyl ester

1-bromo-2,2-diphenylcyclopropanecarboxylic acid

1-Brom-2,2-diphenylcyclopropancarbonsaeure-methylester

1,1-Diphenylethylene

Downstream raw materials:

(-)-(R)-methyl 1-bromo-2,2-diphenylcyclopropanecarboxylate

(-)-(R)-1-Jod-1-methyl-2,2-diphenyl-cyclopropan

(R)-(-)-1-bromo-1-methyl-2,2-diphenylcyclopropane

(S)-1-methyl-2,2-diphenylcyclopropane

Refernces

• 1、 Carlier, Paul R.,Zhang, Yiqun. "The first enantioenriched metalated nitrile possessing macroscopic configurationat stability". . p. 1319 - 1322. Retrieved 2007/12/29.