Technology Process of [9-chloro-1-(2,4-dichlorophenyl)-1,2,3,4-tetrahydropyrimido[1,2-a]benzimidazol-6-yl]methanol
There total 9 articles about [9-chloro-1-(2,4-dichlorophenyl)-1,2,3,4-tetrahydropyrimido[1,2-a]benzimidazol-6-yl]methanol which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
lithium borohydride;
In
tetrahydrofuran;
at 20 ℃;
for 16h;
- Guidance literature:
-
Multi-step reaction with 9 steps
1.1: tetrahydrofuran / 3 h / 0 - 20 °C
1.2: 14 h / 0 - 20 °C
2.1: triethylamine / methanol / 6 h / 50 °C
3.1: hydrogen; palladium 10% on activated carbon / tetrahydrofuran / 23 h / 20 °C
4.1: N-chloro-succinimide / acetonitrile / 17.5 h / 20 °C
5.1: tetrahydrofuran / 72 h / 20 °C
6.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / tetrahydrofuran / 3 h / 50 °C
7.1: pyridine; triethylamine / tetrahydrofuran / 13 h / 0 °C
8.1: potassium carbonate / N,N-dimethyl-formamide / 4 h / 70 °C
9.1: lithium borohydride / tetrahydrofuran / 16 h / 20 °C
With
pyridine; N-chloro-succinimide; lithium borohydride; palladium 10% on activated carbon; hydrogen; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine;
In
tetrahydrofuran; methanol; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/j.bmc.2018.01.020
- Guidance literature:
-
Multi-step reaction with 8 steps
1: triethylamine / methanol / 6 h / 50 °C
2: hydrogen; palladium 10% on activated carbon / tetrahydrofuran / 23 h / 20 °C
3: N-chloro-succinimide / acetonitrile / 17.5 h / 20 °C
4: tetrahydrofuran / 72 h / 20 °C
5: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / tetrahydrofuran / 3 h / 50 °C
6: pyridine; triethylamine / tetrahydrofuran / 13 h / 0 °C
7: potassium carbonate / N,N-dimethyl-formamide / 4 h / 70 °C
8: lithium borohydride / tetrahydrofuran / 16 h / 20 °C
With
pyridine; N-chloro-succinimide; lithium borohydride; palladium 10% on activated carbon; hydrogen; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine;
In
tetrahydrofuran; methanol; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/j.bmc.2018.01.020