Thienyl Fentanyl Hydrochloride

Base Information

• Chemical Name: Thienyl Fentanyl Hydrochloride
• CAS No.: 117332-93-1
• Molecular Formula: C₁₉H₂₄N₂OS*ClH
• Molecular Weight: 364.939
• Mol file: 117332-93-1.mol

Synonyms:Propanamide,N-phenyl-N-[1-(2-thienylmethyl)-4-piperidinyl]-, monohydrochloride (9CI); NIH10493

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Chemical Property of Thienyl Fentanyl Hydrochloride

Chemical Property:

• Melting Point: >232°C (dec.)
• PSA: 51.79000
• LogP: 4.89560
• Storage Temp.: Controlled Substance, -20?C Freezer

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Description: Thienyl fentanyl (hydrochloride) (Item No. 20785) is an analytical reference standard that is structurally categorized as an opioid. The physiological and toxicological properties of this compound are not known. This product is intended for research and forensic applications.
• Uses: Fentanyl analog. A drug opioid. Controlled Substance

Technology Process of Thienyl Fentanyl Hydrochloride

There total 6 articles about Thienyl Fentanyl Hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-phenylmethyl-4-piperidone (3612-20-2) → N-Phenyl-N-<1-(2-thienyl)methyl-4-piperidyl>propanamide Hydrochloride (117332-93-1)

Guidance literature:

Multi-step reaction with 4 steps

1: 1) p-toluenesulfonic acid monohydrate, 2) NaBH₄ / 1) toluene, 22 h, reflux, 2) ethanol, rt, 3 h

2: toluene / 3 h / Heating

3: 95 percent / H₂, conc. HCl / 10 percent Pd/C / ethanol / 50 °C / 2068.6 Torr

4: 2) HCl / 1) CH₂Cl₂, 2) diethyl ether

With hydrogenchloride; sodium tetrahydroborate; hydrogen; toluene-4-sulfonic acid; palladium on activated charcoal; In ethanol; toluene;

DOI:10.1002/jhet.5570260329

Reference yield:

1-benzyl-N-phenylpiperidin-4-amine (1155-56-2) → N-Phenyl-N-<1-(2-thienyl)methyl-4-piperidyl>propanamide Hydrochloride (117332-93-1)

Guidance literature:

Multi-step reaction with 3 steps

1: toluene / 3 h / Heating

2: 95 percent / H₂, conc. HCl / 10 percent Pd/C / ethanol / 50 °C / 2068.6 Torr

3: 2) HCl / 1) CH₂Cl₂, 2) diethyl ether

With hydrogenchloride; hydrogen; palladium on activated charcoal; In ethanol; toluene;

DOI:10.1002/jhet.5570260329

Reference yield:

N-(1-benzyl-4-piperidinyl)-N-phenylpropionamide (1474-02-8) → N-Phenyl-N-<1-(2-thienyl)methyl-4-piperidyl>propanamide Hydrochloride (117332-93-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 95 percent / H₂, conc. HCl / 10 percent Pd/C / ethanol / 50 °C / 2068.6 Torr

2: 2) HCl / 1) CH₂Cl₂, 2) diethyl ether

With hydrogenchloride; hydrogen; palladium on activated charcoal; In ethanol;

DOI:10.1002/jhet.5570260329

upstream raw materials:

2-Chloromethylthiophene

Norfentanyl

1-phenylmethyl-4-piperidone

2-thiophenemethanol

Refernces