Furo[3,2-c]pyridine-4-methanol

Base Information

• Chemical Name: Furo[3,2-c]pyridine-4-methanol
• CAS No.: 117013-87-3
• Molecular Formula: C₈H₇NO₂
• Molecular Weight: 149.149
• DSSTox Substance ID: DTXSID40554113
• Nikkaji Number: J809.517E
• Wikidata: Q82434955
• Mol file: 117013-87-3.mol

Synonyms:117013-87-3;Furo[3,2-c]pyridin-4-ylmethanol;Furo[3,2-c]pyridine-4-methanol (9CI);Furo[3,2-c]pyridine-4-methanol;(Furo[3,2-c]pyridin-4-yl)methanol;DTXSID40554113

Chemical Property of Furo[3,2-c]pyridine-4-methanol

Chemical Property:

• PSA: 46.26000
• LogP: 1.32010
• XLogP3: 0.4
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 149.047678466
• Heavy Atom Count: 11
• Complexity: 140

Purity/Quality:

Furo[3,2-c]pyridine-4-methanol 97.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CN=C(C2=C1OC=C2)CO

Technology Process of Furo[3,2-c]pyridine-4-methanol

There total 2 articles about Furo[3,2-c]pyridine-4-methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-methyl-furo<3,2-c>pyridine (79180-14-6) → 4-hydroxymethyl-furo<3,2-c>pyridine (117013-87-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 58 percent / 33 percent H₂O₂ / acetic acid / 18 h / 100 °C

2: 1.) acetic anhydride, 2.) NaOH / 1.) 100 deg C, 4 h, 2.) 95 percent ethanol, 80 deg C, 20 min

With sodium hydroxide; dihydrogen peroxide; acetic anhydride; In acetic acid;

DOI:10.1016/0223-5234(87)90293-5

Reference yield:

4-methyl-furo<3,2-c>pyridine N-oxide (117013-86-2) → 4-hydroxymethyl-furo<3,2-c>pyridine (117013-87-3)

Guidance literature:

With sodium hydroxide; acetic anhydride; Multistep reaction; 1.) 100 deg C, 4 h, 2.) 95 percent ethanol, 80 deg C, 20 min;

DOI:10.1016/0223-5234(87)90293-5

upstream raw materials:

4-methyl-furo<3,2-c>pyridine N-oxide

4-methyl-furo<3,2-c>pyridine

Refernces