Furo[3,2-c]pyridine,6-methyl-,5-oxide(9CI)

Base Information

• Chemical Name: Furo[3,2-c]pyridine,6-methyl-,5-oxide(9CI)
• CAS No.: 117013-83-9
• Molecular Formula: C₈H₇NO₂
• Molecular Weight: 149.149
• Mol file: 117013-83-9.mol

Synonyms:Furo[3,2-c]pyridine,6-methyl-,5-oxide(9CI)

Chemical Property of Furo[3,2-c]pyridine,6-methyl-,5-oxide(9CI)

Chemical Property:

• PSA: 38.60000
• LogP: 2.16970

Purity/Quality:

6-methyl-Furo[3,2-c]pyridine5-oxide 97.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Furo[3,2-c]pyridine,6-methyl-,5-oxide(9CI)

There total 3 articles about Furo[3,2-c]pyridine,6-methyl-,5-oxide(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

6-methyl-furo<3,2-c>pyridine (117013-82-8) → 6-methyl-furo<3,2-c>pyridine N-oxide (117013-83-9)

Guidance literature:

With dihydrogen peroxide; In acetic acid; at 100 ℃; for 18h;

DOI:10.1016/0223-5234(87)90293-5

Reference yield:

6-methyl-4,5-dihydrofuro<3,2-c>pyridin-4-one (57105-94-9) → 6-methyl-furo<3,2-c>pyridine N-oxide (117013-83-9)

Guidance literature:

Multi-step reaction with 3 steps

1: 66 percent / POCl₃ / 4 h / Heating

2: 75 percent / Zn, acetic acid / Heating

3: 77 percent / 33 percent H₂O₂ / acetic acid / 18 h / 100 °C

With dihydrogen peroxide; acetic acid; zinc; trichlorophosphate; In acetic acid;

DOI:10.1016/0223-5234(87)90293-5

Reference yield:

4-chloro-6-methyl-furo<3,2-c>pyridine (57053-31-3) → 6-methyl-furo<3,2-c>pyridine N-oxide (117013-83-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 75 percent / Zn, acetic acid / Heating

2: 77 percent / 33 percent H₂O₂ / acetic acid / 18 h / 100 °C

With dihydrogen peroxide; acetic acid; zinc; In acetic acid;

DOI:10.1016/0223-5234(87)90293-5

upstream raw materials:

6-methyl-furo<3,2-c>pyridine

6-methyl-4,5-dihydrofuro<3,2-c>pyridin-4-one

4-chloro-6-methyl-furo<3,2-c>pyridine

Downstream raw materials:

6-hydroxymethyl-furo<3,2-c>pyridine

Refernces