BUSULFAN-D8 (TETRAMETHYLENE-D8)

Base Information

• Chemical Name: BUSULFAN-D8 (TETRAMETHYLENE-D8)
• CAS No.: 116653-28-2
• Molecular Formula: C6H6 D8 O6 S2
• Molecular Weight: 254.35
• Mol file: 116653-28-2.mol

Synonyms:BUSULFAN-D8 (TETRAMETHYLENE-D8);Busulfan-D8(tetramethylene);1,4-Butanediol-d8-dimethanesulfonate Esters;Busulfan-d8;Busulfex-d8;Busulphan-d8;CB-2041-d8;GT-41-d8

Chemical Property of BUSULFAN-D8 (TETRAMETHYLENE-D8)

Chemical Property:

• Melting Point: 112-1140C
• Refractive Index: 1.471
• PSA: 103.50000
• LogP: 1.88060
• Storage Temp.: -20°C Freezer

Purity/Quality:

99%min ^*data from raw suppliers

Busulfan-d8 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Description: Busulfan-d8 is intended for use as an internal standard for the quantification of busulfan by GC- or LC-MS. Busulfan is an alkyl sulfonate that acts as an alkylating antineoplastic agent. It forms both intra- and interstrand crosslinks on DNA. In mammals, busulfan causes profound and prolonged reduction in the generation of hematopoietic progenitors without significantly affecting lymphocyte levels or humoral antibody responses.
• Uses: Alkylating agent with antileukemic activity. Antineoplastic

Technology Process of BUSULFAN-D8 (TETRAMETHYLENE-D8)

There total 1 articles about BUSULFAN-D8 (TETRAMETHYLENE-D8) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

methanesulfonyl chloride (124-63-0) + 1,1,2,2,3,3,4,4-octadeutero-1,4-butanediol (74829-49-5) → [1,1,2,2,3,3,4,4-2H8]butane-1,4-diyl bis(methanesulfonate) (116653-28-2)

Guidance literature:

In dichloromethane; triethylamine; at 20 ℃; for 1.5h;

DOI:10.1002/1522-2675(20001108)83:11<2953::AID-HLCA2953>3.0.CO;2-I

Reference yield: 54.0%

[1,1,2,2,3,3,4,4-2H8]butane-1,4-diyl bis(methanesulfonate) (116653-28-2) + (-)-(S)-3-(4-methoxyphenyl)-N-{3-[(4-methylphenylsulfonyl)amino]propyl}-3-({3-[(4-methylphenylsulfonyl)amino]propyl}amino)propanamide (321835-85-2) → (-)-(8S)-8-(4-methoxyphenyl)-1,13-(4-tolylsulfonyl)[14,14,15,15,16,16,17,17-2H8]-1,5,9,13-tetraazacycloheptadecan-6-one (321835-86-3)

Guidance literature:

(-)-(S)-3-(4-methoxyphenyl)-N-{3-[(4-methylphenylsulfonyl)amino]propyl}-3-({3-[(4-methylphenylsulfonyl)amino]propyl}amino)propanamide; With caesium carbonate; In N,N-dimethyl-formamide; at 62 ℃; for 0.5h;

[1,1,2,2,3,3,4,4-2H₈]butane-1,4-diyl bis(methanesulfonate); In N,N-dimethyl-formamide; at 55 ℃; for 48h;

DOI:10.1002/1522-2675(20001108)83:11<2953::AID-HLCA2953>3.0.CO;2-I

Reference yield:

[1,1,2,2,3,3,4,4-2H8]butane-1,4-diyl bis(methanesulfonate) (116653-28-2) + C140H90(2)H40O24 + p-tolyldiazirine (42270-89-3) → C144H88(2)H48O24*C8H8

Guidance literature:

[1,1,2,2,3,3,4,4-2H₈]butane-1,4-diyl bis(methanesulfonate); C₁₄₀H₉₀⁽²⁾H₄₀O₂₄; p-tolyldiazirine; With caesium carbonate; In N,N,N,N,N,N-hexamethylphosphoric triamide; at 20 ℃; for 120h;

In ⁽²⁾H₈-toluene; at -196.16 ℃; Further stages.; UV-irradiation;

DOI:10.1021/ja027831k

upstream raw materials:

methanesulfonyl chloride

1,1,2,2,3,3,4,4-octadeutero-1,4-butanediol

Downstream raw materials:

(-)-(8S)-8-(4-methoxyphenyl)-1,13-(4-tolylsulfonyl)[14,14,15,15,16,16,17,17-2H₈]-1,5,9,13-tetraazacycloheptadecan-6-one

Refernces

• 1、 Nezbedova, Lenka,Drandarov, Konstantin,Werner, Christa,Hesse, Manfred. "The asymmetric synthesis of the [D8]-labeled (-)-(S)-dihydroxyverbacine, the terminal precursor in the biogenesis of the macrobicyclic spermine alkaloids aphelandrine and orantine". . p. 2953 - 2960. Retrieved 2007/10/03.