4-(4-(trifluoromethoxy)styryl)benzonitrile

Base Information

• Chemical Name: 4-(4-(trifluoromethoxy)styryl)benzonitrile
• CAS No.: 1239663-65-0
• Molecular Formula: C₁₆H₁₀F₃NO
• Molecular Weight: 289.257
• Mol file: 1239663-65-0.mol

Synonyms:4-(4-(trifluoromethoxy)styryl)benzonitrile

Chemical Property of 4-(4-(trifluoromethoxy)styryl)benzonitrile

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(4-(trifluoromethoxy)styryl)benzonitrile

There total 3 articles about 4-(4-(trifluoromethoxy)styryl)benzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

2-phenylacrylonitrile (495-10-3) + 1-bromo-4-(trifluoromethoxy)benzene (407-14-7) → 4-(4-(trifluoromethoxy)styryl)benzonitrile (1239663-65-0)

Guidance literature:

With potassium phosphate; palladium diacetate; In N,N-dimethyl acetamide; at 140 ℃; for 12h; Inert atmosphere;

Reference yield:

(Z)-4-(2-bromovinyl)benzonitrile (60592-58-7) + bis-(4-(trifluoromethoxy)phenyl)manganese → 4-(4-(trifluoromethoxy)styryl)benzonitrile (1239663-65-0) + (Z)-4-(4-(trifluoromethoxy)styryl)benzonitrile

Guidance literature:

In tetrahydrofuran; at 0 - 25 ℃; for 1h; Overall yield = 19percent; Schlenk technique; Inert atmosphere;

DOI:10.3390/molecules25030723

Reference yield:

1-bromo-4-(trifluoromethoxy)benzene (407-14-7) → 4-(4-(trifluoromethoxy)styryl)benzonitrile (1239663-65-0) + (Z)-4-(4-(trifluoromethoxy)styryl)benzonitrile

Guidance literature:

Multi-step reaction with 2 steps

1.1: lithium chloride; magnesium / tetrahydrofuran / -5 °C / Schlenk technique; Inert atmosphere

1.2: 1 h / -5 °C / Schlenk technique; Inert atmosphere

2.1: tetrahydrofuran / 1 h / 0 - 25 °C / Schlenk technique; Inert atmosphere

With magnesium; lithium chloride; In tetrahydrofuran;

DOI:10.3390/molecules25030723

upstream raw materials:

2-phenylacrylonitrile

1-bromo-4-(trifluoromethoxy)benzene

(Z)-4-(2-bromovinyl)benzonitrile

Downstream raw materials:

4-[(E)-2-(4-trifluoromethoxyphenyl)-vinyl]-benzaldehyde

Refernces

• 1、 -. "Pesticidal Compositions". Page/Page column 6-7. . Retrieved 2010/08/18.