Technology Process of 2-[N,N-bis-(9,9-dimethylfluoren-2-yl)aminophenyl]-5,5'-bithiophene-2' boronic acid pinacol ester
There total 6 articles about 2-[N,N-bis-(9,9-dimethylfluoren-2-yl)aminophenyl]-5,5'-bithiophene-2' boronic acid pinacol ester which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
2-[N,N-bis-(9,9-dimethylfluoren-2-yl)aminophenyl]-2'-bromo-5,5'-bisthiophene;
With
n-butyllithium;
In
tetrahydrofuran; hexane;
at -78 - 0 ℃;
for 0.583333h;
Inert atmosphere;
2-Isopropoxy-4,4,5,5-tetramethyl-1,3,2-dioxaborolane;
In
tetrahydrofuran; hexane;
at 0 ℃;
for 1h;
Inert atmosphere;
DOI:10.1002/chem.201200020
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: tris(dibenzylideneacetone)dipalladium(0) chloroform complex; potassium tert-butylate; 1,3-bis[2,6-diisopropylphenyl]imidazolium chloride / toluene / 20 h / Inert atmosphere; Reflux
2.1: N-Bromosuccinimide / chloroform / 1 h / 20 °C
3.1: tetrakis(triphenylphosphine) palladium(0); potassium carbonate / tetrahydrofuran; water / 20 h / Inert atmosphere; Reflux
4.1: N-Bromosuccinimide / chloroform / 1 h / 20 °C
5.1: n-butyllithium / tetrahydrofuran; hexane / 0.58 h / -78 - 0 °C / Inert atmosphere
5.2: 1 h / 0 °C / Inert atmosphere
With
tris(dibenzylideneacetone)dipalladium(0) chloroform complex; N-Bromosuccinimide; tetrakis(triphenylphosphine) palladium(0); n-butyllithium; potassium tert-butylate; potassium carbonate; 1,3-bis[2,6-diisopropylphenyl]imidazolium chloride;
In
tetrahydrofuran; hexane; chloroform; water; toluene;
3.1: Suzuki coupling;
DOI:10.1002/chem.201200020
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: N-Bromosuccinimide / chloroform / 1 h / 20 °C
2.1: tetrakis(triphenylphosphine) palladium(0); potassium carbonate / tetrahydrofuran; water / 20 h / Inert atmosphere; Reflux
3.1: N-Bromosuccinimide / chloroform / 1 h / 20 °C
4.1: n-butyllithium / tetrahydrofuran; hexane / 0.58 h / -78 - 0 °C / Inert atmosphere
4.2: 1 h / 0 °C / Inert atmosphere
With
N-Bromosuccinimide; tetrakis(triphenylphosphine) palladium(0); n-butyllithium; potassium carbonate;
In
tetrahydrofuran; hexane; chloroform; water;
2.1: Suzuki coupling;
DOI:10.1002/chem.201200020
