3-(4-bromophenyl)propanoyl chloride

Base Information

• Chemical Name: 3-(4-bromophenyl)propanoyl chloride
• CAS No.: 55394-81-5
• Molecular Formula: C₉H₈BrClO
• Molecular Weight: 247.519
• Mol file: 55394-81-5.mol

Synonyms:3-(4-bromophenyl)propanoyl chloride

Chemical Property of 3-(4-bromophenyl)propanoyl chloride

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

3-(4-bromophenyl)propanoylchloride 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-(4-bromophenyl)propanoyl chloride

There total 9 articles about 3-(4-bromophenyl)propanoyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

3-(4-bromophenyl)propionic acid (1643-30-7) → 3-(4-bromophenyl)propanoyl chloride (55394-81-5)

Guidance literature:

With oxalyl dichloride; In dichloromethane; at 40 ℃; for 2h;

Reference yield:

1-bromomethyl-4-bromobenzene (589-15-1) → 3-(4-bromophenyl)propanoyl chloride (55394-81-5)

Guidance literature:

Multi-step reaction with 4 steps

1.1: NaH / 1,2-dimethoxy-ethane / 2 h / 20 °C

1.2: 57 percent / 1,2-dimethoxy-ethane / 18 h / Heating

2.1: aq. KOH / 4.5 h / Heating

3.1: aq. H₂SO₄ / 18 h / Heating

4.1: (COCl)2; DMF / 18 h / 20 °C

With potassium hydroxide; oxalyl dichloride; sulfuric acid; sodium hydride; N,N-dimethyl-formamide; In 1,2-dimethoxyethane;

DOI:10.1021/jm020067s

Reference yield:

trans-4-bromocinnamic acid (1200-07-3,5676-63-1,17916-60-8) → 3-(4-bromophenyl)propanoyl chloride (55394-81-5)

Guidance literature:

Multi-step reaction with 2 steps

1: H₂ / Pd/C / methanol

2: (COCl)2 / CH₂Cl₂

With oxalyl dichloride; hydrogen; palladium on activated charcoal; In methanol; dichloromethane;

DOI:10.1016/j.bmcl.2005.01.019

upstream raw materials:

3-(4-bromophenyl)propionic acid

trans-4-bromocinnamic acid

4-bromo-benzaldehyde

diethyl 2-(4-bromobenzyl)malonate

Downstream raw materials:

4-(3-(4-bromophenyl)propyl)morpholine

3-(4-bromophenyl)-1-morpholinopropan-1-one

3-(4-bromophenyl)-N-methoxy-N-methylpropanamide

6-bromo-3,4-dihydro-1H-quinolin-2-one

Refernces

• 1、 Ali, Ahmed I. M.,O'Donnell, Martin J.,Samaritoni, J. Geno,Scott, William L.. "A solid-phase synthetic route to N-acylated α-alkyl-D,L-homoserine lactones". supporting information. . Retrieved 2020/09/04.
• 2、 Nozawa-Kumada, Kanako,Saga, Satoshi,Matsuzawa, Yuta,Hayashi, Masahito,Shigeno, Masanori,Kondo, Yoshinori. "Copper-Catalyzed Oxidative Benzylic C(sp3)?H Cyclization for the Synthesis of β-Lactams". supporting information. p. 4496 - 4499. Retrieved 2020/04/10.