Technology Process of (2S)-Nω-(6-aminohexanoyl)-N-[2-(3,5-dioxo-1,2-diphenyl-1,2,4-triazolidin-4-yl)ethyl]-Nα-[2-(1-{2-oxo-2-[4-(6-oxo-6,11-dihydro-5H-dibenzo[b,e]azepin-11-yl)piperazin-1-yl]ethyl}cyclopentyl)acetyl]argininamide
There total 17 articles about (2S)-Nω-(6-aminohexanoyl)-N-[2-(3,5-dioxo-1,2-diphenyl-1,2,4-triazolidin-4-yl)ethyl]-Nα-[2-(1-{2-oxo-2-[4-(6-oxo-6,11-dihydro-5H-dibenzo[b,e]azepin-11-yl)piperazin-1-yl]ethyl}cyclopentyl)acetyl]argininamide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 3 steps
1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine / water; N,N-dimethyl-formamide / 16 h / 20 °C
2: mercury dichloride; triethylamine / N,N-dimethyl-formamide / 16 h / 20 °C
3: trifluoroacetic acid / dichloromethane / 2 h / 20 °C
With
benzotriazol-1-ol; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; mercury dichloride;
In
dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1002/cmdc.201200566
- Guidance literature:
-
With
trifluoroacetic acid;
In
dichloromethane;
at 20 ℃;
for 2h;
DOI:10.1002/cmdc.201100241
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: dichloromethane / 18 h / 20 °C
2.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / acetonitrile / 16 h / 0 - 20 °C
3.1: hydrazine hydrate / methanol / 16 h / 20 °C
3.2: 3 h / 20 °C
4.1: triethylamine; mercury dichloride / N,N-dimethyl-formamide / 16 h / 20 °C
5.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C
With
benzotriazol-1-ol; hydrazine hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; mercury dichloride;
In
methanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1002/cmdc.201100241