C₁₈H₁₅NO

Base Information

• Chemical Name: C₁₈H₁₅NO
• CAS No.: 1379664-46-6
• Molecular Formula: C₁₈H₁₅NO
• Molecular Weight: 261.323
• Mol file: 1379664-46-6.mol

Synonyms:C₁₈H₁₅NO

Chemical Property of C₁₈H₁₅NO

Chemical Property:

Purity/Quality:

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Technology Process of C₁₈H₁₅NO

There total 2 articles about C₁₈H₁₅NO which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

C23H25NO3 (1379664-45-5) → C18H15NO (1379664-46-6)

Guidance literature:

C₂₃H₂₅NO₃; With silica gel; trifluoroacetic acid; In dichloromethane; at 20 ℃; for 1h;

With sodium nitrite; In dichloromethane; at 20 ℃; for 2h;

With triethylamine; In dichloromethane; at 20 ℃; for 0.5h;

DOI:10.1002/chem.201200167

Reference yield:

4-(1-Propynyl)biphenyl (61948-01-4) → C18H15NO (1379664-46-6)

Guidance literature:

Multi-step reaction with 2 steps

1.1: nickel⁽⁰⁾(1,5-cyclooctadiene)2; triphenylphosphine / 1,4-dioxane / 17 h / 90 °C / Inert atmosphere

2.1: silica gel; trifluoroacetic acid / dichloromethane / 1 h / 20 °C

2.2: 2 h / 20 °C

2.3: 0.5 h / 20 °C

With silica gel; nickel⁽⁰⁾(1,5-cyclooctadiene)2; triphenylphosphine; trifluoroacetic acid; In 1,4-dioxane; dichloromethane;

DOI:10.1002/chem.201200167

upstream raw materials:

C₂₃H₂₅NO₃

4-(1-Propynyl)biphenyl

Refernces