hexaazidoneomycin B

Base Information

• Chemical Name: hexaazidoneomycin B
• CAS No.: 468065-21-6
• Molecular Formula: C₂₃H₃₄N₁₈O₁₃
• Molecular Weight: 770.636
• Mol file: 468065-21-6.mol

Synonyms:hexaazidoneomycin B

Chemical Property of hexaazidoneomycin B

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of hexaazidoneomycin B

There total 3 articles about hexaazidoneomycin B which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

neomycin B (119-04-0) → hexaazidoneomycin B (468065-21-6)

Guidance literature:

With triflic azide; copper(II) sulfate; triethylamine; Inert atmosphere;

DOI:10.1021/jm900028n

Reference yield: 82.0%

neomycin B sulphate (25389-98-4) → hexaazidoneomycin B (468065-21-6)

Guidance literature:

With triflic azide; triethylamine; copper(II) sulfate; In methanol; dichloromethane; water; for 18h;

DOI:10.1021/ja0264605

Reference yield:

neomycin B trisulfate (4146-30-9,25389-98-4,28002-70-2,34289-38-8,92283-95-9) → hexaazidoneomycin B (468065-21-6)

Guidance literature:

With triflic azide; copper(II) sulfate; triethylamine; In methanol; dichloromethane; water; for 18h; Ambient temperature;

DOI:10.1021/ja9910356

upstream raw materials:

neomycin B trisulfate

neomycin B

neomycin B sulphate

Downstream raw materials:

1,3,2',6'-tetraazido-3',4'-di-O-acetylneamine

1,3,2′,6′-tetraazidoneamine

1,3,2′,6′-tetraazido-6,3′,4′-tri-O-acetylneamine

2,5,3′,4′-tetra-O-acetyl-2′,6′-diazido-1-phenylthio-β-neobiosamine

Refernces

• 1、 Granqvist, Lotta,T?htinen, Ville,Virta, Pasi. "Synthesis of glycosidic (β-1′′→6, 3′ and 4′) site isomers of neomycin B and their effect on RNA and DNA triplex stability". . . Retrieved 2019/02/10.
• 2、 Suarez, Jose Ramon,Trastoy, Beatriz,Perez-Ojeda, M. Eugenia,Marin-Barrios, Ruben,Chiara, Jose Luis. "Nonafluorobutanesulfonyl azide: A shelf-stable diazo transfer reagent for the synthesis of azides from primary amines". supporting information; scheme or table. p. 2515 - 2520. Retrieved 2011/02/22.