3-Pyridinecarbonyl chloride, 2-fluoro- (9CI)

Base Information

• Chemical Name: 3-Pyridinecarbonyl chloride, 2-fluoro- (9CI)
• CAS No.: 119899-26-2
• Molecular Formula: C6H3 Cl F N O
• Molecular Weight: 159.547
• Hs Code.: 29333990
• Mol file: 119899-26-2.mol

Synonyms:2-Fluoronicotinoylchloride; 2-Fluoropyridine-3-carbonyl chloride

Chemical Property of 3-Pyridinecarbonyl chloride, 2-fluoro- (9CI)

Chemical Property:

• PSA: 29.96000
• LogP: 1.59970
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

98% ^*data from raw suppliers

2-FluoronicotinoylChloride ^*data from reagent suppliers

Safty Information:

• Statements: 34
• Safety Statements: 26-27-36/37/39-45

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-Pyridinecarbonyl chloride, 2-fluoro- (9CI)

There total 3 articles about 3-Pyridinecarbonyl chloride, 2-fluoro- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.7%

2-fluoronicotinic acid (393-55-5) → 2-fluoronicotinic acid chloride (119899-26-2)

Guidance literature:

With thionyl chloride; for 48h; Reflux;

Reference yield:

3-methylpyridin-2-ylamine (1603-40-3) → 2-fluoronicotinic acid chloride (119899-26-2)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium nitrite; aqueous tetrafluoroboric acid / Diazotization

2: aqueous KMnO₄

3: SOCl₂

With potassium permanganate; tetrafluoroboric acid; thionyl chloride; sodium nitrite;

DOI:10.1021/ja01171a518

Reference yield:

2-fluoro-3-methylpyridine (2369-18-8) → 2-fluoronicotinic acid chloride (119899-26-2)

Guidance literature:

Multi-step reaction with 2 steps

1: aqueous KMnO₄

2: SOCl₂

With potassium permanganate; thionyl chloride;

DOI:10.1021/ja01171a518

upstream raw materials:

2-fluoronicotinic acid

3-methylpyridin-2-ylamine

2-fluoro-3-methylpyridine

Downstream raw materials:

2-fluoronicotinamide

2-methylpyrido[2,3-d]pyrimidin-4(3H)-one

2-methoxy-3H-pyrido[2,3-d]pyrimidin-4-one

2-phenylpyrido<2,3-d>pyrimidin-4(3H)-one

Refernces

• 1、 Yang, Yu-Dong,He, Ying-Hui,Ma, Kun-Yuan,Li, Hu,Zhang, Zhi-Jun,Sun, Yu,Wang, Yu-Ling,Hu, Guan-Fang,Wang, Ren-Xuan,Liu, Ying-Qian. "Design and Discovery of Novel Antifungal Quinoline Derivatives with Acylhydrazide as a Promising Pharmacophore". . p. 8347 - 8357. Retrieved 2021/08/16.
• 2、 Hou, Weijie,Ren, Yan,Zhang, Zhenhua,Sun, Huan,Ma, Yongfen,Yan, Bo. "Novel quinazoline derivatives bearing various 6-benzamide moieties as highly selective and potent EGFR inhibitors". . p. 1740 - 1750. Retrieved 2018/03/12.