Technology Process of 3-(1-benzoyl-piperidin-4-yl)-N-hydroxy-propionamide
There total 5 articles about 3-(1-benzoyl-piperidin-4-yl)-N-hydroxy-propionamide which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 6 steps
1: oxalyl dichloride / dichloromethane; dimethyl sulfoxide / 0.25 h / -60 °C / Inert atmosphere
2: tetrahydrofuran / 20 °C
3: palladium 10% on activated carbon; hydrogen / methanol
4: hydrogenchloride / 1,4-dioxane
5: N-ethyl-N,N-diisopropylamine / dichloromethane
6: hydroxylamine hydrochloride; sodium hydroxide / methanol
With
hydrogenchloride; oxalyl dichloride; palladium 10% on activated carbon; hydroxylamine hydrochloride; hydrogen; N-ethyl-N,N-diisopropylamine; sodium hydroxide;
In
tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; dimethyl sulfoxide;
2: Wittig reaction;
DOI:10.1016/j.bmcl.2011.02.085
- Guidance literature:
-
Multi-step reaction with 5 steps
1: tetrahydrofuran / 20 °C
2: palladium 10% on activated carbon; hydrogen / methanol
3: hydrogenchloride / 1,4-dioxane
4: N-ethyl-N,N-diisopropylamine / dichloromethane
5: hydroxylamine hydrochloride; sodium hydroxide / methanol
With
hydrogenchloride; palladium 10% on activated carbon; hydroxylamine hydrochloride; hydrogen; N-ethyl-N,N-diisopropylamine; sodium hydroxide;
In
tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane;
1: Wittig reaction;
DOI:10.1016/j.bmcl.2011.02.085