DL-Phenylalanine-obzl p-tosylate

Base Information

• Chemical Name: DL-Phenylalanine-obzl p-tosylate
• CAS No.: 119290-61-8
• Molecular Formula: C23H25NO5S
• Molecular Weight: 427.51
• Mol file: 119290-61-8.mol

Synonyms:DL-Phenylalanine benzyl ester p-toluene-sulfonate;

Chemical Property of DL-Phenylalanine-obzl p-tosylate

Chemical Property:

• Melting Point: 149 °C(Solv: water (7732-18-5))
• Boiling Point: 382.8 °C at 760 mmHg
• Flash Point: 220.3 °C
• PSA: 115.07000
• LogP: 5.32260
• Storage Temp.: Store at RT.

Purity/Quality:

98%Min ^*data from raw suppliers

DL-Phenylalanine benzyl ester 4-toluenesulfonate salt ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of DL-Phenylalanine-obzl p-tosylate

There total 1 articles about DL-Phenylalanine-obzl p-tosylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Phenylalanine (150-30-1,25191-15-5,658-69-5,67675-33-6) + toluene-4-sulfonic acid (104-15-4) + benzyl alcohol (100-51-6,185532-71-2) → (±)‐phenylalanine benzyl ester p-toluenesulfonic acid (119290-61-8)

Guidance literature:

In cyclohexane; water; for 4h; Dean-Stark; Reflux;

DOI:10.1007/s00726-017-2400-y

Reference yield: 89.0%

2-phthalimidobenzoic acid (41513-78-4) + (±)‐phenylalanine benzyl ester p-toluenesulfonic acid (119290-61-8) → 2-[2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-benzoylamino]-3-phenyl-propionic acid benzyl ester

Guidance literature:

With benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; In N,N-dimethyl-formamide;

DOI:10.1055/s-2001-15060

Reference yield: 84.0%

O-benzylhydoxylamine hydrochloride (2687-43-6) + (±)‐phenylalanine benzyl ester p-toluenesulfonic acid (119290-61-8) + 1,1'-carbonyldiimidazole (530-62-1) → C24H24N2O4

Guidance literature:

O-benzylhydoxylamine hydrochloride; 1,1'-carbonyldiimidazole; With triethylamine; In dichloromethane; at 20 ℃; for 1h;

(±)‐phenylalanine benzyl ester p-toluenesulfonic acid; In dichloromethane; at 20 ℃; for 4h;

DOI:10.1016/S0968-0896(00)00235-2

upstream raw materials:

Phenylalanine

toluene-4-sulfonic acid

benzyl alcohol

Downstream raw materials:

(+/-)-N-Diphenyl-phosphoro-phenyl-alanin-benzylester

D-2-carbamoylamino-3-phenylpropionic acid

Refernces