3-Pyridinamine,6-(1-piperazinyl)-(9CI)

Base Information

• Chemical Name: 3-Pyridinamine,6-(1-piperazinyl)-(9CI)
• CAS No.: 119285-06-2
• Molecular Formula: C9H14 N4
• Molecular Weight: 178.237
• Hs Code.: 2933998090
• Mol file: 119285-06-2.mol

Synonyms:1-(5-Aminopyridin-2-yl)piperazine;6-(Piperazin-1-yl)pyridin-3-amine

Chemical Property of 3-Pyridinamine,6-(1-piperazinyl)-(9CI)

Chemical Property:

• PSA: 54.18000
• LogP: 1.04840

Purity/Quality:

98%min ^*data from raw suppliers

6-Piperazin-1-ylpyridin-3-amine 98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-Pyridinamine,6-(1-piperazinyl)-(9CI)

There total 4 articles about 3-Pyridinamine,6-(1-piperazinyl)-(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

1-(5-nitro-2-pyridinyl)piperazine (82205-58-1) → 6-(piperazin-1-yl)pyridin-3-amine (119285-06-2)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In ethanol; ethyl acetate; at 70 ℃; for 0.5h; under 750.075 Torr; H-Cube;

DOI:10.1016/j.tetlet.2011.07.147

Reference yield:

2-chloro-5-nitropyridine (4548-45-2) → 6-(piperazin-1-yl)pyridin-3-amine (119285-06-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 84.6 percent / acetonitrile / 2.5 h / 20 °C

2: H₂ / Pd/C / tetrahydrofuran / 20 °C / 760 Torr

With hydrogen; palladium on activated charcoal; In tetrahydrofuran; acetonitrile;

DOI:10.1016/j.ejmech.2004.10.012

Reference yield:

2-bromo-5-nitropyridine (4487-59-6) → 6-(piperazin-1-yl)pyridin-3-amine (119285-06-2)

Guidance literature:

Multi-step reaction with 3 steps

1.1: potassium carbonate / water / 0.25 h / 150 °C / Microwave irradiation

2.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C / Inert atmosphere

2.2: 20 °C

3.1: palladium 10% on activated carbon; hydrogen / ethanol; ethyl acetate / 0.5 h / 70 °C / 750.08 Torr / H-Cube.(TM).

With palladium 10% on activated carbon; hydrogen; potassium carbonate; trifluoroacetic acid; In ethanol; dichloromethane; water; ethyl acetate;

DOI:10.1016/j.tetlet.2011.07.147

upstream raw materials:

1-(5-nitro-2-pyridinyl)piperazine

2-chloro-5-nitropyridine

2-bromo-5-nitropyridine

tert-butyl 4-(5-nitropyridin-2-yl)piperazine-1-carboxylate

Downstream raw materials:

N-(3-{6-[4-(4-amino-benzenesulfonyl)-piperazin-1-yl]-pyridin-3-yl}-2-oxo-oxazolidin-5-ylmethyl)-acetamide

N-(3-{6-[4-(4-nitro-benzenesulfonyl)-piperazin-1-yl]-pyridin-3-yl}-2-oxo-oxazolidin-5-ylmethyl)-acetamide

4-{5-[(S)-5-(Acetylamino-methyl)-2-oxo-oxazolidin-3-yl]-pyridin-2-yl}-piperazine-1-carboxylic acid benzyl ester

4-[5-((R)-5-Methanesulfonyloxymethyl-2-oxo-oxazolidin-3-yl)-pyridin-2-yl]-piperazine-1-carboxylic acid benzyl ester

Refernces

• 1、 Wang, Xiao-Jun,Wu, Ning,Du, Guang-Jian,Zhao, Shuang-Qi,Yan, Ming,Gu, Lian-Quan. "Synthesis and antibacterial activities of eperezolid analogs with glycinyl substitutions". scheme or table. p. 377 - 385. Retrieved 2009/10/23.