4-hydroxy-N-phenylbenzothioamide

Base Information

• Chemical Name: 4-hydroxy-N-phenylbenzothioamide
• CAS No.: 4270-58-0
• Molecular Formula: C₁₃H₁₁NOS
• Molecular Weight: 229.302
• Mol file: 4270-58-0.mol

Synonyms:4-hydroxy-N-phenylbenzothioamide

Chemical Property of 4-hydroxy-N-phenylbenzothioamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-hydroxy-N-phenylbenzothioamide

There total 5 articles about 4-hydroxy-N-phenylbenzothioamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

4-hydroxy-benzaldehyde (123-08-0,65581-83-1) + aniline (62-53-3) → 4-hydroxy-N-phenylbenzothioamide (4270-58-0)

Guidance literature:

With sulfur; In N,N-dimethyl-formamide; at 110 ℃; for 8h;

DOI:10.1016/j.apcata.2012.03.012

Reference yield: 80.0%

phenyl isothiocyanate (103-72-0) + phenol (108-95-2,27073-41-2) → 4-hydroxy-N-phenylbenzothioamide (4270-58-0)

Guidance literature:

With aluminium trichloride; In nitromethane; for 7h; Ambient temperature;

DOI:10.1055/s-1988-27685

Reference yield:

4-amino-benzoic acid anilide (782-45-6) → 4-hydroxy-N-phenylbenzothioamide (4270-58-0)

Guidance literature:

Multi-step reaction with 2 steps

1: xylene; phosphorus (V)-sulfide

2: aqueous hydrochloric acid; sodium nitrite / anschliessend Erhitzen der mit Wasser verduennten Reaktionsloesung

With hydrogenchloride; phosphorous (V) sulfide; xylene; sodium nitrite;

DOI:10.1002/hlca.19320150133

upstream raw materials:

phenyl isothiocyanate

phenol

4-amino-benzoic acid anilide

4-nitrobenzanilide

Downstream raw materials:

4-methoxy-N-phenyl-thiobenzimidic acid methyl ester

4-methoxy-N-phenylthiobenzamide

4-hydroxybenzanilide

Refernces

• 1、 Pathare, Sagar P.,Chaudhari, Pramod S.,Akamanchi, Krishnacharya G.. "Sulfated tungstate: An efficient catalyst for synthesis of thioamides via Kindler reaction". experimental part. p. 125 - 129. Retrieved 2012/07/03.