dimethyl 2-cyclohexylidenesuccinate

Base Information

• Chemical Name: dimethyl 2-cyclohexylidenesuccinate
• CAS No.: 40745-21-9
• Molecular Formula: C₁₂H₁₈O₄
• Molecular Weight: 226.273
• Mol file: 40745-21-9.mol

Synonyms:dimethyl 2-cyclohexylidenesuccinate

Chemical Property of dimethyl 2-cyclohexylidenesuccinate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of dimethyl 2-cyclohexylidenesuccinate

There total 8 articles about dimethyl 2-cyclohexylidenesuccinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

dimethyl cis-but-2-ene-1,4-dioate (624-48-6) + 1-nitrocyclohexane (1122-60-7) → dimethyl 2-cyclohexylidenesuccinate (40745-21-9)

Guidance literature:

With 1,8-diazabicyclo[5.4.0]undec-7-ene; In acetonitrile; at 25 ℃; for 7h;

DOI:10.1016/S0040-4020(99)00829-7

Reference yield: 80.0%

dimethylfumarate (624-49-7) + 1-nitrocyclohexane (1122-60-7) → dimethyl 2-cyclohexylidenesuccinate (40745-21-9)

Guidance literature:

With 1,8-diazabicyclo[5.4.0]undec-7-ene; In acetonitrile; at 20 ℃; for 1h;

DOI:10.1002/1099-0690(200008)2000:16<2927::aid-ejoc2927>3.3.co;2-p

Reference yield: 60.0%

cyclohexanone (108-94-1,11119-77-0,9003-41-2,9075-99-4) + Dimethyl succinate (106-65-0) → dimethyl 2-cyclohexylidenesuccinate (40745-21-9)

Guidance literature:

Dimethyl succinate; With potassium tert-butylate; In tert-butyl alcohol; Inert atmosphere;

cyclohexanone; In tert-butyl alcohol; at 25 ℃; Inert atmosphere;

With sulfuric acid; In methanol; for 8h; Reflux;

DOI:10.1055/s-0029-1219233

upstream raw materials:

carbon monoxide

1-Ethynylcyclohexan-1-ol

diazomethane

3-cyclohexylidene-4-methoxy-4-oxobutanoic acid

Downstream raw materials:

2-[1-Benzo[1,3]dioxol-5-yl-meth-(E)-ylidene]-3-cyclohexylidene-succinic acid

2-Cyclohexylidene-3-[1-(3,4-dimethoxy-phenyl)-meth-(E)-ylidene]-succinic acid

2-Cyclohexylidene-3-[1-(4-methoxy-phenyl)-meth-(E)-ylidene]-succinic acid

2-Cyclohexylidene-3-[1-(3-methoxy-phenyl)-meth-(E)-ylidene]-succinic acid

Refernces

• 1、 Patel, Ramesh M.,Argade, Narshinha P.. "Bromine-induced facile synthesis of butenolides and spirobutenolides from sterically congested tetrasubstituted dialkyl alkylidene succinates". experimental part. p. 1188 - 1194. Retrieved 2010/05/19.
• 2、 Ballini, Roberto,Bosica, Giovanna,Damiani, Marco,Righi, Paolo. "Nitroalkanes as a new source of 2-alkylidene-1,4-diols, in two steps". . p. 13451 - 13456. Retrieved 2007/10/03.