1-(2,4-dimethoxyphenyl)-2-nitroethanone

Base Information

• Chemical Name: 1-(2,4-dimethoxyphenyl)-2-nitroethanone
• CAS No.: 14367-88-5
• Molecular Formula: C₁₀H₁₁NO₅
• Molecular Weight: 225.201
• Mol file: 14367-88-5.mol

Synonyms:1-(2,4-dimethoxyphenyl)-2-nitroethanone

Chemical Property of 1-(2,4-dimethoxyphenyl)-2-nitroethanone

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of 1-(2,4-dimethoxyphenyl)-2-nitroethanone

There total 3 articles about 1-(2,4-dimethoxyphenyl)-2-nitroethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C10H13NO5 → 1-(2,4-dimethoxyphenyl)-2-nitroethanone (14367-88-5)

Guidance literature:

With pyridinium chlorochromate; In dichloromethane; at 0 - 20 ℃; Inert atmosphere;

DOI:10.1002/chem.201302117

Reference yield:

2,4-Dimethoxybenzaldehyde (613-45-6) → 1-(2,4-dimethoxyphenyl)-2-nitroethanone (14367-88-5)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium acetate / ethanol / 24 h / 20 °C / Inert atmosphere

2: pyridinium chlorochromate / dichloromethane / 0 - 20 °C / Inert atmosphere

With sodium acetate; pyridinium chlorochromate; In ethanol; dichloromethane; 1: |Henry Nitro Aldol Condensation;

DOI:10.1002/chem.201302117

Reference yield:

nitromethane (75-52-5) + 2,4-Dimethoxybenzaldehyde (613-45-6) → 1-(2,4-dimethoxyphenyl)-2-nitroethanone (14367-88-5)

Guidance literature:

Multistep reaction; (i) Et₃N, (ii) CrO₃, AcOH;

upstream raw materials:

nitromethane

2,4-Dimethoxybenzaldehyde

Refernces