C₁₃H₁₆F₃NO₂

Base Information

• Chemical Name: C₁₃H₁₆F₃NO₂
• CAS No.: 857934-67-9
• Molecular Formula: C₁₃H₁₆F₃NO₂
• Molecular Weight: 275.271
• Mol file: 857934-67-9.mol

Synonyms:C₁₃H₁₆F₃NO₂

Chemical Property of C₁₃H₁₆F₃NO₂

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of C₁₃H₁₆F₃NO₂

There total 1 articles about C₁₃H₁₆F₃NO₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 34.0%

3,3,3-trifluoro-2-methoxy-2-methyl methyl propionate (857934-65-7) + (R)-1-phenyl-ethyl-amine (3886-69-9) → C13H16F3NO2 (857934-68-0) + C13H16F3NO2 (857934-67-9)

Guidance literature:

(R)-1-phenyl-ethyl-amine; With methylmagnesium chloride; In tetrahydrofuran; at 5 - 15 ℃;

3,3,3-trifluoro-2-methoxy-2-methyl methyl propionate; In tetrahydrofuran; at 15 - 20 ℃;

DOI:10.1016/j.jfluchem.2009.11.015

Reference yield: 89.0%

C13H16F3NO2 (857934-67-9) → (S)-2-trifluoromethyllactic acid (24435-45-8)

Guidance literature:

With water; hydrogen bromide; at 115 ℃; for 24h;

DOI:10.1016/j.jfluchem.2009.11.015

upstream raw materials:

3,3,3-trifluoro-2-methoxy-2-methyl methyl propionate

(R)-1-phenyl-ethyl-amine

Downstream raw materials:

(S)-2-trifluoromethyllactic acid

Refernces

• 1、 -. "METHOD FOR PRODUCING OPTICALLY ACTIVE 3,3,3-TRIFLUORO-2-HYDROXYPROPIONIC ACID DERIVATIVE". Page/Page column 26. . Retrieved 2010/02/13.