4-bromo-2-isopropoxybenzoic acid

Base Information

• Chemical Name: 4-bromo-2-isopropoxybenzoic acid
• CAS No.: 1038595-51-5
• Molecular Formula: C₁₀H₁₁BrO₃
• Molecular Weight: 259.1
• Mol file: 1038595-51-5.mol

Synonyms:4-bromo-2-isopropoxybenzoic acid

Chemical Property of 4-bromo-2-isopropoxybenzoic acid

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

4-Bromo-2-(propan-2-yloxy)benzoicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-bromo-2-isopropoxybenzoic acid

There total 1 articles about 4-bromo-2-isopropoxybenzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-fluoro-4-bromobenzoic acid (112704-79-7) + isopropyl alcohol (67-63-0,8013-70-5) → 4-bromo-2-isopropoxybenzoic acid (1038595-51-5)

Guidance literature:

With sodium hydride; In N,N-dimethyl-formamide; at 20 ℃;

DOI:10.1021/jm701324c

Reference yield: 99.0%

4-bromo-2-isopropoxybenzoic acid (1038595-51-5) + 3-oxetanamine (21635-88-1) → 4-bromo-2-isopropoxy-N-(oxetan-3-yl)benzamide

Guidance literature:

With triethylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In dichloromethane; at 20 ℃; for 18h;

Reference yield: 90.0%

4-bromo-2-isopropoxybenzoic acid (1038595-51-5) + tert-butyl ((1R,2S)-2-amino-2-(3-chlorophenyl)-1-(4-chlorophenyl)-ethyl)carbamate → tert-butyl ((1R,2S)-2-(4-bromo-2-isopropoxybenzamido)-2-(3-chlorophenyl)-1-(4-chlorophenyl)ethyl)carbamate

Guidance literature:

With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 0 - 20 ℃; for 16h;

DOI:10.1021/jo501003r

upstream raw materials:

2-fluoro-4-bromobenzoic acid

isopropyl alcohol

Downstream raw materials:

methyl 4-bromo-2-isopropoxybenzoate

3-isopropoxy-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoic acid

Refernces