4-methyl-2-(1-phenylvinyl)pyridine

Base Information

• Chemical Name: 4-methyl-2-(1-phenylvinyl)pyridine
• CAS No.: 1581709-76-3
• Molecular Formula: C₁₄H₁₃N
• Molecular Weight: 195.264
• Mol file: 1581709-76-3.mol

Synonyms:4-methyl-2-(1-phenylvinyl)pyridine

Chemical Property of 4-methyl-2-(1-phenylvinyl)pyridine

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of 4-methyl-2-(1-phenylvinyl)pyridine

There total 5 articles about 4-methyl-2-(1-phenylvinyl)pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

bromobenzene (108-86-1,52753-63-6) + 3,5-dimethyl-[1,2,3]triazolo[1,5-a]pyridine (1384956-00-6) → 4-methyl-2-(1-phenylvinyl)pyridine (1581709-76-3)

Guidance literature:

With (bis(tricyclohexyl)phosphine)palladium(II) dichloride; nickel(II) acetate tetrahydrate; potassium carbonate; In toluene; at 130 ℃; for 24h; Inert atmosphere; Sealed tube;

DOI:10.1002/adsc.201500967

Reference yield: 72.0%

1-(4-methylpyridin-2-yl)-1-phenylethanol (107455-67-4) → 4-methyl-2-(1-phenylvinyl)pyridine (1581709-76-3)

Guidance literature:

With sulfuric acid; In water; at 100 ℃; for 0.25h; Inert atmosphere;

DOI:10.1021/acs.orglett.5b01746

Reference yield:

2-benzyl-4-methyl pyridine (5191-54-8) + N,N-dimethyl acetamide (127-19-5,116057-81-9) → 4-methyl-2-(1-phenylvinyl)pyridine (1581709-76-3) + 2-(1-phenylvinyl)-4-vinylpyridine (1581709-77-4)

Guidance literature:

With sodium persulfate; copper(II) acetate monohydrate; at 120 ℃; for 4h; Overall yield = 52 %; Overall yield = 51 mg; Inert atmosphere;

DOI:10.1021/ol500655k

upstream raw materials:

2-benzyl-4-methyl pyridine

N,N-dimethyl acetamide

1-(4-methylpyridin-2-yl)-1-phenylethanol

2-acetyl-4-methylpyridine

Refernces

• 1、 Chaitanya, Manthena,Anbarasan, Pazhamalai. "Rhodium-Catalyzed Cyanation of C(sp2)-H Bond of Alkenes". supporting information. p. 3766 - 3769. Retrieved 2015/08/18.