3-DIMETHYLAMINOBENZOYL CHLORIDE HYDROCHLORIDE

Base Information

• Chemical Name: 3-DIMETHYLAMINOBENZOYL CHLORIDE HYDROCHLORIDE
• CAS No.: 117500-61-5
• Molecular Formula: C9H10 Cl N O . Cl H
• Molecular Weight: 220.098
• Hs Code.: 2921490090
• Mol file: 117500-61-5.mol

Synonyms:Benzoylchloride, 3-(dimethylamino)-, hydrochloride (9CI); Benzoyl chloride,m-dimethylamino-, hydrochloride (6CI); 3-Dimethylaminobenzoyl chloridehydrochloride

Chemical Property of 3-DIMETHYLAMINOBENZOYL CHLORIDE HYDROCHLORIDE

Chemical Property:

• Vapor Pressure: 0.000441mmHg at 25°C
• Melting Point: 131-133°C
• Boiling Point: 310.5°Cat760mmHg
• Flash Point: 141.6°C
• PSA: 20.31000
• Density: g/cm³
• LogP: 2.13160
• Sensitive.: Moisture Sensitive

Purity/Quality:

98%Min ^*data from raw suppliers

3-DimethylaminobenzoylChlorideHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s): R34:
• Hazard Codes: R34:
• Statements: 34
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-DIMETHYLAMINOBENZOYL CHLORIDE HYDROCHLORIDE

There total 1 articles about 3-DIMETHYLAMINOBENZOYL CHLORIDE HYDROCHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

oxalyl dichloride (79-37-8) + 3-(dimethylamino)benzoic acid (99-64-9) → 3-(dimethylamino)benzoyl chloride hydrochloride (117500-61-5)

Guidance literature:

In N-methyl-acetamide; dichloromethane;

Reference yield: 56.0%

N-(5-amino-2-chloro-4-fluorophenyl)phthalimide (250683-91-1) + 3-(dimethylamino)benzoyl chloride hydrochloride (117500-61-5) → N-(5-amino-4-chloro-2-fluorophenyl)phthalimide-3-dimethylaminobenzamide

Guidance literature:

With pyridine; In dichloromethane;

Reference yield: 48.0%

3-(dimethylamino)benzoyl chloride hydrochloride (117500-61-5) + 5-[(3R)-3-aminopiperidin-1-yl]-3-[(3-methyl-1,2-thiazol-5-yl)amino]pyrazine-2-carboxamide → 5-[(3R)-3-[3-(dimethylamino)benzamido]piperidin-1-yl]-3-[(3-methyl-1,2-thiazol-5-yl)amino]pyrazine-2-carboxamide hydrochloride

Guidance literature:

3-(dimethylamino)benzoyl chloride hydrochloride; 5-[(3R)-3-aminopiperidin-1-yl]-3-[(3-methyl-1,2-thiazol-5-yl)amino]pyrazine-2-carboxamide; With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 1h;

With hydrogenchloride; In methanol; dichloromethane; at 20 ℃; for 1h;

upstream raw materials:

oxalyl dichloride

3-(dimethylamino)benzoic acid

Downstream raw materials:

N-(3-amino-4-chlorophenyl)-3-dimethylaminobenzamide

N-(4-chloro-2-fluoro-5-phthalimidophenyl)-3-dimethylaminobenzamide

Refernces