H-9 DIHYDROCHLORIDE

Base Information

• Chemical Name: H-9 DIHYDROCHLORIDE
• CAS No.: 116700-36-8
• Molecular Formula: C11H13 N3 O2 S . 2 Cl H
• Molecular Weight: 324.231
• Hs Code.: 2935009090
• Mol file: 116700-36-8.mol

Synonyms:5-Isoquinolinesulfonamide,N-(2-aminoethyl)-, dihydrochloride (9CI); H 9; H 9 Dihydrochloride

Chemical Property of H-9 DIHYDROCHLORIDE

Chemical Property:

• Melting Point: 250-255°C dec.
• PSA: 93.46000
• LogP: 4.24780
• Storage Temp.: −20°C

Purity/Quality:

99% ^*data from raw suppliers

H-9 dihydrochloride ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Useful:

• Uses: A potent competitive inhibitor of protein kinase C, cGMP-, and cAMP-dependent protein kinase with respect to ATP

Technology Process of H-9 DIHYDROCHLORIDE

There total 3 articles about H-9 DIHYDROCHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.2%

ethylenediamine (107-15-3,85404-18-8) + isoquinoline-5-sulfonyl chloride hydrochloride (105627-79-0) → C20H18N4O4S2 + H-9 (116700-36-8)

Guidance literature:

With sodium hydrogencarbonate; In dichloromethane; at 20 ℃; for 2h; Large scale;

DOI:10.1021/acs.oprd.1c00211

Reference yield: 60.0%

ethylenediamine (107-15-3,85404-18-8) + isoquinoline-5-sulfonyl chloride hydrochloride (105627-79-0) → H-9 (116700-36-8)

Guidance literature:

With sodium hydrogencarbonate; In dichloromethane; at 0 - 5 ℃; Large scale;

DOI:10.1021/acs.oprd.1c00211

Reference yield:

5-isoquinolinesulfonyl chloride (84468-15-5) + ethylenediamine (107-15-3,85404-18-8) → H-9 (116700-36-8)

Guidance literature:

In dichloromethane; for 1h; Yield given; Ambient temperature;

DOI:10.1021/jm00121a009

upstream raw materials:

5-isoquinolinesulfonyl chloride

ethylenediamine

isoquinoline-5-sulfonyl chloride hydrochloride

Downstream raw materials:

Isoquinoline-5-sulfonic acid [2-(N',N''-diphenyl-guanidino)-ethyl]-amide; hydrochloride

N-{2-[(isoquinoline-5-sulfonyl)amino]ethyl}cyclohexanecarboxamide

fasudil hydrochloride

HA 1004 hydrochloride

Refernces

• 1、 Morikawa,Sone,Asano. "5-Isoquinolinesulfonamide derivatives. 1. Synthesis and vasodilatory activity of N-(2-guanidinoethyl)-5-isoquinolinesulfonamide derivatives". . p. 42 - 46. Retrieved 2007/10/02.