2-Phenyl-3-methylquinoxaline

Base Information

• Chemical Name: 2-Phenyl-3-methylquinoxaline
• CAS No.: 10130-23-1
• Molecular Formula: C15H12 N2
• Molecular Weight: 220.274
• Hs Code.: 2933990090
• Mol file: 10130-23-1.mol

Synonyms:2-Methyl-3-phenylquinoxaline;NSC 405266

Chemical Property of 2-Phenyl-3-methylquinoxaline

Chemical Property:

• Vapor Pressure: 0.000112mmHg at 25°C
• Melting Point: 57-58 °C
• Boiling Point: 346.8°Cat760mmHg
• PKA: 0?+-.0.48(Predicted)
• Flash Point: 145.9°C
• PSA: 25.78000
• Density: 1.149g/cm³
• LogP: 3.60520

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-Phenyl-3-methylquinoxaline ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Description: 2-phenyl-3-methyl-Quinoxaline is a synthetic intermediate useful for pharmaceutical synthesis.

Technology Process of 2-Phenyl-3-methylquinoxaline

There total 46 articles about 2-Phenyl-3-methylquinoxaline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

1,2-diamino-benzene (95-54-5) + 1-Phenylpropane-1,2-dione (579-07-7) → 2-methyl-3-phenylquinoxaline (10130-23-1)

Guidance literature:

With amberlyst-15; In water; at 70 ℃; for 0.166667h;

DOI:10.1080/00397910903219401

Reference yield: 97.0%

1,2-diamino-benzene (95-54-5) + benzil (134-81-6) → 2-methyl-3-phenylquinoxaline (10130-23-1)

Guidance literature:

With saccharin; In methanol; at 20 ℃; for 0.166667h;

DOI:10.1080/00397911.2013.795596

Reference yield: 97.0%

1-phenylpropadiene (2327-99-3) + 1,2-diamino-benzene (95-54-5) → 2-methyl-3-phenylquinoxaline (10130-23-1) + 1-benzyl-2-phenyl-1H-1,3-benzimidazole (739-88-8)

Guidance literature:

1-phenylpropadiene; With silver tetrafluoroborate; (triphenylphosphine)gold(I) chloride; sulfuric acid; water; In 1,4-dioxane; at 60 ℃; for 24h;

1,2-diamino-benzene; With oxalic acid; In ethanol; water; at 80 ℃; for 4h;

DOI:10.3762/bjoc.7.98

upstream raw materials:

diphenylether

2-azido-1-phenyl-1-propanone

1,2-diamino-benzene

1-Phenylpropane-1,2-dione

Downstream raw materials:

2-(2-nitropropenyl)-4-phenylpyrrolo[1,2-a]quinoxaline

ethyl 4-methyl-3-(4'-phenylpyrrolo[1,2-a]quinoxalin-2'-yl)-1H-pyrrole-2-carboxylate

3-phenyl-2-quinoxalinecarbonitrile

2-phenyl-3-(trichloromethyl)quinoxaline

Refernces

• 1、 Shi, Shuai,Wang, Tao,Yang, Weibo,Rudolph, Matthias,Hashmi, A. Stephen K.. "Gold-catalyzed synthesis of glyoxals by oxidation of terminal alkynes: One-pot synthesis of quinoxalines". . p. 6576 - 6580. Retrieved 2013.
• 2、 Lin, Pei-Ying,Hou, Rei-Sheu,Wang, Huey-Min,Kang, Iou-Jiun,Chen, Ling-Ching. "Hypervalent iodine(iii) sulfonate mediated synthesis of quinoxalines in liquid peg-400". . p. 683 - 687. Retrieved 2009.
• 3、 More, Shivaji V.,Sastry,Wang, Chieh-Chieh,Yao, Ching-Fa. "Molecular iodine: A powerful catalyst for the easy and efficient synthesis of quinoxalines". . p. 6345 - 6348. Retrieved 2005.
• 4、 Padmavathy,Nagendrappa, Gopalpur,Geetha. "A rapid synthesis of quinoxalines starting from ketones". . p. 544 - 547. Retrieved 2011.
• 5、 Hazarika, Parasa,Gogoi, Pranjal,Konwar, Dilip. "Efficient and green method for the synthesis of 1,5-benzodiazepine and quinoxaline derivatives in water". . p. 3447 - 3454. Retrieved 2007.
• 6、 Liu, Ju-Yan,Liu, Jing,Wang, Jia-Di,Jiao, De-Quan,Liu, Hai-Wang. "Efficient, ecofriendly, and practical process for the synthesis of quinoxalines catalyzed by amberlyst-15 in aqueous media". . p. 2047 - 2056. Retrieved 2010.
• 7、 Lassagne, Frédéric,Chevallier, Floris,Roisnel, Thierry,Dorcet, Vincent,Mongin, Florence,Domingo, Luis R.. "A Combined Experimental and Theoretical Study of the Ammonium Bifluoride Catalyzed Regioselective Synthesis of Quinoxalines and Pyrido[2,3- b ]pyrazines". . p. 2680 - 2689. Retrieved 2015.
• 8、 Fathi, Safoura,Sardarian, Ali Reza. "Nitrilotris(Methylenephosphonic Acid) as a New Highly Efficient and Recyclable Br?Nested Acid Catalyst for the Synthesis of Quinoxaline Derivatives under Mild and Green Conditions". . p. 1471 - 1478. Retrieved 2015.
• 9、 Barluenga, Jose,Aznar, Fernando,Liz, Ramon,Cabal, Maria-Paz. "One-Pot Synthesis of Quinoxalines and 2,3-Dihydropyrazines via Oxidative Aminomercuriation of Propargyl Alcohols". . p. 313 - 314. Retrieved 1985.
• 10、 Manna, Srimanta,Kong, Wei-Jun,B?ckvall, Jan-E.. "Iron(II)-Catalyzed Aerobic Biomimetic Oxidation of N-Heterocycles". supporting information. p. 13725 - 13729. Retrieved 2021/09/08.