3-CHLORO-6-HYDROXY (1H)INDAZOLE

Base Information

• Chemical Name: 3-CHLORO-6-HYDROXY (1H)INDAZOLE
• CAS No.: 116570-49-1
• Molecular Formula: C7H5 Cl N2 O
• Molecular Weight: 168.583
• Mol file: 116570-49-1.mol

Synonyms:3-CHLORO-6-HYDROXY (1H)INDAZOLE

Chemical Property of 3-CHLORO-6-HYDROXY (1H)INDAZOLE

Chemical Property:

• Melting Point: 210 °C
• Boiling Point: 399.1±22.0 °C(Predicted)
• PKA: 8.73±0.40(Predicted)
• PSA: 48.91000
• Density: 1.598±0.06 g/cm3(Predicted)
• LogP: 1.92190
• Storage Temp.: 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

3-Chloro-6-hydroxy(1H)indazole ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-CHLORO-6-HYDROXY (1H)INDAZOLE

There total 2 articles about 3-CHLORO-6-HYDROXY (1H)INDAZOLE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-chloro-6-amino-1H-indazole (21413-23-0) → 3-chloro-6-hydroxy-1H-indazole (116570-49-1)

Guidance literature:

With sulfuric acid; at 180 - 190 ℃; unter Druck;

Reference yield:

→ 3-chloro-6-hydroxy-1H-indazole (116570-49-1)

Guidance literature:

3-Chlor-6-amino-indazol in wss. H2SO4 <190grad>;

Reference yield:

3-chloro-6-hydroxy-1H-indazole (116570-49-1) → axitinib (319460-85-0,885126-40-9)

Guidance literature:

Multi-step reaction with 10 steps

1: sodium hydroxide; dimethyl sulfate

2: sodium; magnesium / diethyl ether / Heating

3: hydrogenchloride; zinc(II) chloride / water / Heating

4: 2 h / 300 °C / Sealed tube

5: hydrogen iodide

6: iron(III) chloride; sulfuric acid / water

7: trichlorophosphate; trifluoromethylsulfonic anhydride

8: 1 h / Heating

9: chlorine

10: sodium hydroxide / ethanol

With hydrogenchloride; iron(III) chloride; trifluoromethylsulfonic anhydride; sulfuric acid; hydrogen iodide; sodium; chlorine; magnesium; dimethyl sulfate; sodium hydroxide; zinc(II) chloride; trichlorophosphate; In diethyl ether; ethanol; water;

upstream raw materials:

3-chloro-6-amino-1H-indazole

Downstream raw materials:

C₂₂H₂₀N₄OS

axitinib

3-chloro-6-methoxy-1H-indazole